Targeting ligand–receptor interactions for development of cancer therapeutics
JW Kim, JR Cochran - Current opinion in chemical biology, 2017 - Elsevier
Highlights•Ligands and receptors have been identified as important oncology
targets.•Biodistribution, regulation, and function help dictate whether to target a ligand or …
targets.•Biodistribution, regulation, and function help dictate whether to target a ligand or …
Bisphenol A induces proliferative effects on both breast cancer cells and vascular endothelial cells through a shared GPER-dependent pathway in hypoxia
F Xu, X Wang, N Wu, S He, W Yi, S Xiang, P Zhang… - Environmental …, 2017 - Elsevier
Based on the breast cancer cells and the vascular endothelial cells are both estrogen-
sensitive, we proposed a close reciprocity existed between them in the tumor …
sensitive, we proposed a close reciprocity existed between them in the tumor …
Surface modification of microparticles causes differential uptake responses in normal and tumoral human breast epithelial cells
The use of micro-and nanodevices as multifunctional systems for biomedical applications
has experienced an exponential growth during the past decades. Although a large number …
has experienced an exponential growth during the past decades. Although a large number …
[HTML][HTML] Comparative evaluation of dimeric and monomeric forms of ADAPT scaffold protein for targeting of HER2-expressing tumours
ADAPTs are small engineered non-immunoglobulin scaffold proteins, which have
demonstrated very promising features as vectors for radionuclide tumour targeting …
demonstrated very promising features as vectors for radionuclide tumour targeting …
[HTML][HTML] Identification of caveolin-1 as a potential causative factor in the generation of trastuzumab resistance in breast cancer cells
The oncogenic tyrosine kinase receptor ErbB2 is a prognostic factor and target for breast
cancer therapeutics. In contrast with the other ErbB receptors, ErbB2 is hardly internalized …
cancer therapeutics. In contrast with the other ErbB receptors, ErbB2 is hardly internalized …
A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells
TA Bailey, H Luan, E Tom, TA Bielecki… - Journal of Biological …, 2014 - ASBMB
ErbB2 overexpression drives oncogenesis in 20–30% cases of breast cancer. Oncogenic
potential of ErbB2 is linked to inefficient endocytic traffic into lysosomes and preferential …
potential of ErbB2 is linked to inefficient endocytic traffic into lysosomes and preferential …
Efficient drug delivery of paclitaxel glycoside: A novel solubility gradient encapsulation into liposomes coupled with immunoliposomes preparation
T Shigehiro, T Kasai, M Murakami, SC Sekhar… - PloS one, 2014 - journals.plos.org
Although the encapsulation of paclitaxel into liposomes has been extensively studied, its
significant hydrophobic and uncharged character has generated substantial difficulties …
significant hydrophobic and uncharged character has generated substantial difficulties …
[HTML][HTML] HER2-specific recombinant immunotoxin 4D5scFv-PE40 passes through retrograde trafficking route and forces cells to enter apoptosis
E Sokolova, E Guryev, A Yudintsev, V Vodeneev… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Immunotoxin 4D5scFv-PE40 is a recombinant protein that comprises 4D5scFv
antibody as a targeting module and fragment of Pseudomonas exotoxin A as an effector …
antibody as a targeting module and fragment of Pseudomonas exotoxin A as an effector …
The weak link: optimization of the ligand–nanoparticle interface to enhance Cancer Cell Targeting by Polymer Micelles
J Wang, M Dzuricky, A Chilkoti - Nano letters, 2017 - ACS Publications
Many promising targeting ligands are hydrophobic peptides, and these ligands often show
limited accessibility to receptors, resulting in suboptimal targeting. A systematic study to …
limited accessibility to receptors, resulting in suboptimal targeting. A systematic study to …
Development of a novel liposomal nanodelivery system for bioluminescence imaging and targeted drug delivery in ErbB2-overexpressing metastatic ovarian …
XJ Han, YF Wei, YY Wan, LP Jiang… - International …, 2014 - spandidos-publications.com
Liposomes as targeted drug delivery systems are an emerging strategy in the treatment of
cancer to selectively target tumors or genes. In this study, we generated the recombinant …
cancer to selectively target tumors or genes. In this study, we generated the recombinant …