Overview of the 2022 WHO classification of paragangliomas and pheochromocytomas

O Mete, SL Asa, AJ Gill, N Kimura, RR de Krijger… - Endocrine …, 2022 - Springer
This review summarizes the classification of tumors of the adrenal medulla and extra-
adrenal paraganglia as outlined in the 5th series of the WHO Classification of Endocrine and …

Recent advances in the developmental origin of neuroblastoma: an overview

M Ponzoni, T Bachetti, MV Corrias, C Brignole… - Journal of Experimental …, 2022 - Springer
Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …

Spatiotemporal structure of cell fate decisions in murine neural crest

R Soldatov, M Kaucka, ME Kastriti, J Petersen… - Science, 2019 - science.org
Neural crest cells are embryonic progenitors that generate numerous cell types in
vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become …

Single-cell characterization of malignant phenotypes and developmental trajectories of adrenal neuroblastoma

R Dong, R Yang, Y Zhan, HD Lai, CJ Ye, XY Yao… - Cancer Cell, 2020 - cell.com
Neuroblastoma (NB), which is a subtype of neural-crest-derived malignancy, is the most
common extracranial solid tumor occurring in childhood. Despite extensive research, the …

Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin

P Kameneva, AV Artemov, ME Kastriti, L Faure… - Nature …, 2021 - nature.com
Abstract Characterization of the progression of cellular states during human embryogenesis
can provide insights into the origin of pediatric diseases. We examined the transcriptional …

Schwann cell precursors represent a neural crest‐like state with biased multipotency

ME Kastriti, L Faure, D Von Ahsen… - The EMBO …, 2022 - embopress.org
Schwann cell precursors (SCPs) are nerve‐associated progenitors that can generate
myelinating and non‐myelinating Schwann cells but also are multipotent like the neural …

Riding the crest to get a head: neural crest evolution in vertebrates

ML Martik, ME Bronner - Nature Reviews Neuroscience, 2021 - nature.com
In their seminal 1983 paper, Gans and Northcutt proposed that evolution of the vertebrate
'new head'was made possible by the advent of the neural crest and cranial placodes. The …

Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment

M Zethoven, L Martelotto, A Pattison, B Bowen… - Nature …, 2022 - nature.com
Pheochromocytomas (PC) and paragangliomas (PG) are rare neuroendocrine tumors
associated with autonomic nerves. Here we use single-nuclei RNA-seq and bulk-tissue …

Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

G Kildisiute, WM Kholosy, MD Young, K Roberts… - Science …, 2021 - science.org
Neuroblastoma is a childhood cancer that resembles developmental stages of the neural
crest. It is not established what developmental processes neuroblastoma cancer cells …

Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology

SW Guo - Reproduction, 2022 - rep.bioscientifica.com
In brief Traditionally viewed as enigmatic and elusive, adenomyosis is a fairly common
gynecological disease but is under-recognized and under-researched. This review …