Intensive research over the past 2 decades has implicated ceramide in the regulation of
several cell responses. However, emerging evidence points to dramatic complexities in …

Abstract Sphingosine‐1‐phosphate (S1P) is a signalling lipid that regulates many cellular
processes in mammals. One well‐studied role of S1P signalling is to modulate T‐cell …

Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …

Sphingolipids are bioactive lipids found in cell membranes that exert a critical role in signal
transduction. In recent years, it has become apparent that sphingolipids participate in …

Sphingolipids represent a class of diverse bioactive lipid molecules that are increasingly
appreciated as key modulators of diverse physiologic and pathophysiologic processes that …

Sphingolipids are a class of bioactive lipids, which are key modulators of an increasing
number of physiologic and pathophysiologic processes that include cell cycle, apoptosis …

Sphingolipids are structural components in the plasma membranes of eukaryotic cells. Their
metabolism produces bioactive signaling molecules that modulate fundamental cellular …

In all eukaryotes, the plasma membrane is critically important as it maintains the
architectural integrity of the cell. Proper anchorage and interaction between the plasma …

Sphingosine kinase 1 (SK1) is an enzyme that catalyzes the phosphorylation of sphingosine
to produce the bioactive lipid sphingosine 1-phosphate (S1P). We demonstrate here that the …

Studies over the past two decades have identified ceramide as a multifunctional central
molecule in the sphingolipid biosynthetic pathway. Given its diverse tumor suppressive …