Functions of antibodies

DN Forthal - Microbiology spectrum, 2014 - Am Soc Microbiol
Antibodies can impact pathogens in the presence or in the absence of effector cells or
effector molecules such as complement, and experiments can often sort out with precision …

[HTML][HTML] Glycosaminoglycan-protein interactions and their roles in human disease

D Shi, A Sheng, L Chi - Frontiers in molecular biosciences, 2021 - frontiersin.org
Glycosaminoglycans (GAGs) are a family of linear and negatively charged polysaccharides
that exist ubiquitously on the human cell surface as well as in the extracellular matrix. GAGs …

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

M Wahlgren, S Goel, RR Akhouri - Nature Reviews Microbiology, 2017 - nature.com
Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …

[HTML][HTML] Targeting human cancer by a glycosaminoglycan binding malaria protein

A Salanti, TM Clausen, MØ Agerbæk, N Al Nakouzi… - Cancer cell, 2015 - cell.com
Plasmodium falciparum engineer infected erythrocytes to present the malarial protein,
VAR2CSA, which binds a distinct type chondroitin sulfate (CS) exclusively expressed in the …

Malaria's deadly grip: cytoadhesion of Plasmodium falciparum‐infected erythrocytes

JD Smith, JA Rowe, MK Higgins… - Cellular …, 2013 - Wiley Online Library
Cytoadhesion of P lasmodium falciparum‐infected erythrocytes to host microvasculature is a
key virulence determinant. Parasite binding is mediated by a large family of clonally variant …

New insights into malaria pathogenesis

CA Moxon, MP Gibbins, D McGuinness… - Annual Review of …, 2020 - annualreviews.org
Malaria remains a major public health threat in tropical and subtropical regions across the
world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 …

[HTML][HTML] The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner

MØ Agerbæk, SR Bang-Christensen, MH Yang… - Nature …, 2018 - nature.com
Isolation of metastatic circulating tumor cells (CTCs) from cancer patients is of high value for
disease monitoring and molecular characterization. Despite the development of many new …

Malaria biomimetic for tumor targeted drug delivery

J Pihl, TM Clausen, J Zhou, N Krishnan… - acs Nano, 2023 - ACS Publications
Malaria infected erythrocytes utilize the parasite protein VAR2CSA to bind to a unique
presentation of chondroitin sulfate (CS) for their placenta specific tropism. Interestingly …

PfEMP1–a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis

L Hviid, ATR Jensen - Advances in parasitology, 2015 - Elsevier
Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …