Cell migration is essential for many biological processes, while abnormal cell migration is
characteristic of cancer cells. Epithelial cells become motile by undergoing epithelial-to …

Melanoma cells are notorious for their high plasticity and ability to switch back and forth
between various melanoma cell states, enabling the adaptation to sub-optimal conditions …

Architectural proteins are essential epigenetic regulators that play a critical role in
organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a …

Multigene assays can provide insight into key biological processes and prognostic
information to guide development and selection of adjuvant cancer therapy. We report a …

Abstract The Brother of the Regulator of Imprinted Sites (BORIS), as a specific indicator of
hepatocellular carcinoma, exhibits a significant increase in expression. However, its …

Estrogen receptor alpha (ERα) signaling pathway is essential for ERα-positive breast cancer
progression and endocrine therapy resistance. Bromodomain PHD Finger Transcription …

The cancer-testis antigen CTCFL/BORIS (Brother of Regulator of Imprinted Sites) also
known, as a paralog of CTCF-the “master weaver of the genome” is a key transcriptional …

Background Pervasive usage of alternative promoters leads to the deregulation of gene
expression in carcinogenesis and may drive the emergence of new genes in …

Abstract Background Chromatin regulators (CRs) are critical epigenetic modifiers and have
been reported to play critical roles during the progression of various tumors, but their role in …

High-grade serous ovarian carcinoma (HGSC) is the most lethal gynecologic malignancy
due to the lack of reliable biomarkers, effective treatment, and chemoresistance. Improving …