Synapsins (Syns) are phosphoproteins strongly involved in neuronal development and
neurotransmitter release. Three distinct genes SYN1, SYN2 and SYN3, with elevated …

Neurodevelopmental and late-onset neurodegenerative disorders present as separate
entities that are clinically and neuropathologically quite distinct. However, recent evidence …

Aluminium, despite being extremely widespread in the world, is a non-essential metal to
human metabolism. This metal is known to have toxic effects on a variety of organs including …

The NLRP inflammasome is a multi-protein complex which mainly consists of the nucleotide-
binding oligomerization domain, leucine-rich repeat, and pyrin domain. Its activation is …

The alteration and aggregation of alpha-synuclein (α-syn) play a crucial role in
neurodegenerative diseases collectively termed as synucleinopathies, including Parkinson's …

Abstract α-Synuclein (α-Syn) is closely related to the pathogenesis of Parkinson's disease
(PD). Under pathological conditions, the conformation of α-syn changes and different forms …

Parkinson's disease (PD) is a neurodegenerative disease characterized by the
degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and …

Parkinson's disease (PD) is characterized by the loss of nigrostriatal dopaminergic neurons
and the presence of Lewy bodies (LB), intraneuronal inclusions mainly composed of α …

Fibrillary aggregated α-synuclein (α-syn) deposition in Lewy bodies (LB) characterizes
Parkinson's disease (PD) and is believed to trigger dopaminergic synaptic failure and a …

Amyloids were conventionally referred to as extracellular and intracellular accumulation of
Aβ42 peptide, which causes the formation of plaques and neurofibrillary tangles inside the …