Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Currently, biomechanics of living cells is in the focus of interest due to noticeable capability
of such techniques like atomic force microscopy (AFM) to probe cellular properties at the …

The invention of optical tweezers more than three decades ago has opened new avenues in
the study of the mechanical properties of biological molecules and cells. Quantitative force …

Advances in methods that determine cell mechanical phenotype, or mechanotype, have
demonstrated the utility of biophysical markers in clinical and research applications ranging …

The rapidly growing field of mechanobiology demands for robust and reproducible
characterization of cell mechanical properties. Recent achievements in understanding the …

Significance: Optical trapping is a technique capable of applying minute forces that has
been applied to studies spanning single molecules up to microorganisms. Aim: The goal of …

Glioblastoma (GBM) and meningothelial meningioma (MM) are the most frequent malignant
and benign brain lesions, respectively. Mechanical cues play a major role in the progression …

Background Tumor microenvironment consists of the extracellular matrix (ECM), stromal
cells, such as fibroblasts (FBs) and cancer associated fibroblasts (CAFs), and a myriad of …

Over the past decades, increasing evidence has indicated that mechanical loads can
regulate the morphogenesis, proliferation, migration, and apoptosis of living cells …