Cancer metastasis to bones increases the risk of fragility fracture by altering bone
metabolism and disrupting bone structure. Osteocytes, which organize a dense network that …

The impact of metabolic stress induced by obesity on the bone marrow melanoma niche is
largely unknown. Here we employed diet induced obese mice model, where mice received …

Denosumab is a monoclonal antibody against RANK ligand with a role in the prevention of
skeletal-related events and is also known to possess antitumor properties. In this …

Bone metastasis is a common complication of certain cancers such as melanoma. The
spreading of cancer cells into the bone is supported by changes in the bone marrow …

The incidence of malignant melanoma is increasing worldwide and is one of the major
causes of skin cancer deaths in the United States. Although melanoma has the potential to …

Melanoma is a malignant tumor that predominantly arises in the skin. In rare cases,
however, it can manifest in the bone too. In this paper, a primary malignant melanoma of the …

Vulvar cancer is a rare malignancy of the genital tract, the fourth most common type in this
category. The most common form of the clinical appearance is long-lasting pruritus, a lump …

Известно, что опухолевое микроокружение является активным участником в развитии
злокачественных новообразований. Микроокружение опухоли это функциональная …

Tumor microenvironment is known to be an active participant of tumor development. Tumor
microenvironment is functional cell community interacting with cancer cells and promoting …