DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy
R Huang, PK Zhou - Signal transduction and targeted therapy, 2021 - nature.com
Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …
DNA repair, genome stability and cancer: a historical perspective
PA Jeggo, LH Pearl, AM Carr - Nature Reviews Cancer, 2016 - nature.com
The multistep process of cancer progresses over many years. The prevention of mutations
by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance …
by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance …
Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
Milestones of Lynch syndrome: 1895–2015
HT Lynch, CL Snyder, TG Shaw, CD Heinen… - Nature Reviews …, 2015 - nature.com
Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …
condition, is characterized by the predisposition to a spectrum of cancers, primarily …
Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside
Colorectal cancers (CRCs) with deficient mismatch repair (dMMR) or microsatellite instability-
high (MSI-H) often have sustained responses to immune checkpoint inhibitors (ICIs) …
high (MSI-H) often have sustained responses to immune checkpoint inhibitors (ICIs) …
ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes
S Syngal, RE Brand, JM Church… - Official journal of the …, 2015 - journals.lww.com
This guideline presents recommendations for the management of patients with hereditary
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …
Microsatellite instability in colorectal cancer
Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …
Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells
A Belcheva, T Irrazabal, SJ Robertson, C Streutker… - Cell, 2014 - cell.com
The etiology of colorectal cancer (CRC) has been linked to deficiencies in mismatch repair
and adenomatous polyposis coli (APC) proteins, diet, inflammatory processes, and gut …
and adenomatous polyposis coli (APC) proteins, diet, inflammatory processes, and gut …
Genomic instability—an evolving hallmark of cancer
S Negrini, VG Gorgoulis, TD Halazonetis - Nature reviews Molecular …, 2010 - nature.com
Genomic instability is a characteristic of most cancers. In hereditary cancers, genomic
instability results from mutations in DNA repair genes and drives cancer development, as …
instability results from mutations in DNA repair genes and drives cancer development, as …