Organoids

Z Zhao, X Chen, AM Dowbaj, A Sljukic… - Nature Reviews …, 2022 - nature.com
Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

[HTML][HTML] Advances and challenges in stem cell culture

C McKee, GR Chaudhry - Colloids and surfaces B: Biointerfaces, 2017 - Elsevier
Stem cells (SCs) hold great promise for cell therapy, tissue engineering, and regenerative
medicine as well as pharmaceutical and biotechnological applications. They have the …

[HTML][HTML] Microfluidic platforms for cell cultures and investigations

ML Coluccio, G Perozziello, N Malara, E Parrotta… - Microelectronic …, 2019 - Elsevier
This review covers several aspects of microfluidic devices used for culturing and monitoring
of both adherent and non-adherent cells, including a multitude of applications. A comparison …

Engineering prostate cancer in vitro: what does it take?

A Buskin, E Scott, R Nelson, L Gaughan, CN Robson… - Oncogene, 2023 - nature.com
A key challenge in the clinical management and cause of treatment failure of prostate cancer
(PCa) is its molecular, cellular and clinical heterogeneity. Modelling systems that fully …

Controlling stem cell fate with material design

RA Marklein, JA Burdick - Advanced materials, 2010 - Wiley Online Library
Advances in our understanding of stem cell interactions with their environment are leading
to the development of new materials‐based approaches to control stem cell behavior toward …

An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells

H Tsutsui, B Valamehr, A Hindoyan, R Qiao… - Nature …, 2011 - nature.com
A major challenge in stem cell-mediated regenerative medicine is the development of
defined culture systems for the maintenance of clinical-grade human embryonic stem (hES) …

Cell mechanics in embryoid bodies

K Zeevaert, MH Elsafi Mabrouk, W Wagner, R Goetzke - Cells, 2020 - mdpi.com
Embryoid bodies (EBs) resemble self-organizing aggregates of pluripotent stem cells that
recapitulate some aspects of early embryogenesis. Within few days, the cells undergo a …

Mass transfer limitations in embryoid bodies during human embryonic stem cell differentiation

AP Van Winkle, ID Gates, MS Kallos - Cells Tissues Organs, 2012 - karger.com
Due to their ability to differentiate into cell types from all the three germ layers and their
potential unlimited capacity for expansion, embryonic stem cells have tremendous potential …

In situ generation of human brain organoids on a micropillar array

Y Zhu, L Wang, H Yu, F Yin, Y Wang, H Liu, L Jiang… - Lab on a Chip, 2017 - pubs.rsc.org
Brain organoids derived from human induced pluripotent stem cells can recapitulate the
early stages of brain development, representing a powerful in vitro system for modeling …

Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation

AM Bratt-Leal, RL Carpenedo, MD Ungrin… - Biomaterials, 2011 - Elsevier
Biomaterials are increasingly being used to engineer the biochemical and biophysical
properties of the extracellular stem cell microenvironment in order to tailor niche …