Mitochondria are intracellular organelles involved in energy production, cell metabolism and
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …

Autophagy and mitophagy act in cancer as bimodal processes, whose differential functions
strictly depend on cancer ontogenesis, progression, and type. For instance, they can act to …

Estrogens and estrogen-like molecules can modify the biology of several cell types.
Estrogen receptors alpha (ERα) and beta (ERβ) belong to the so-called classical family of …

Due to the limited capacity of the adult mammalian brain to self-repair and regenerate,
neurological diseases, especially neurodegenerative disorders and stroke, characterized by …

Cancer stem cells (CSCs) play a key role in regulating tumorigenesis, progression, as well
as recurrence, and possess typical metabolic characteristics. Autophagy is a catabolic …

Adult neurogenesis has been convincingly demonstrated in two regions of the mammalian
brain: the sub-granular zone (SGZ) of the dentate gyrus (DG) in the hippocampus, and the …

Neural stem cells (NSCs) differentiate into both neurons and glia, and strategies using
human NSCs have the potential to restore function following spinal cord injury (SCI) …

In mammals, new neurons can be generated from neural stem cells in specific regions of the
adult brain. Neural stem cells are characterized by their abilities to differentiate into all …

Mitochondrial dysfunctions critically impair nervous system development and are potentially
involved in the pathogenesis of various neurodevelopmental disorders, including Down …

Stroke remains the number one cause of morbidity in the United States. Within weeks to
months after an ischemic event, there is a resolution of inflammation and evidence of …