Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are widely distributed metalloenzymes in
both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon …

At present more than 250 FDA approved chlorine containing drugs were available in the
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …

A new series of benzimidazole, 1, 2, 4-triazole, and 1, 3, 5-triazine derivatives were
designed and synthesized using a microwave irradiation synthetic approach utilizing 2 …

An effective strategy for successful chemotherapy relies on creating compounds with high
selectivity against cancer cells compared to normal cells and relatively low cytotoxicity. One …

Cancer is one of the leading causes of death across the world, and the prevalence and
mortality rates of cancer will continue to grow. Chemotherapeutics play a critical role in …

The treatment of chronic neuropathic pain remains one of the most challenging of all
neurological diseases and very much an art. There exists no consensus for the optimal …

Due to the pivotal role of carbonic anhydrase IX (CA IX) in pathological conditions, there's a
pressing need for novel inhibitors to improve patient outcomes and clinical management …

This article summarizes the most recent advancements in the synthetic and pharmacological
approaches along with the structure activity relationship towards the s-triazine and its …

A library of twenty two novel 1, 2, 3-triazole benzenesulfonamides incorporating
thiosemicarbazide, 5 (4 H)-thione-1, 2, 4-triazole and variously substituted phenacyl …

A series of twenty four hydroxy-trifluoromethylpyrazoline-carbonyl-1, 2, 3-triazoles and four
hydrazones bearing benzenesulfonamide moieties was obtained by condensation of …