Optimization of metabolomic data processing using NOREVA

J Fu, Y Zhang, Y Wang, H Zhang, J Liu, J Tang… - Nature protocols, 2022 - nature.com
A typical output of a metabolomic experiment is a peak table corresponding to the intensity
of measured signals. Peak table processing, an essential procedure in metabolomics, is …

[HTML][HTML] Liver fibrosis in non-alcoholic fatty liver disease: from liver biopsy to non-invasive biomarkers in diagnosis and treatment

LJM Heyens, D Busschots, GH Koek, G Robaeys… - Frontiers in …, 2021 - frontiersin.org
An increasing percentage of people have or are at risk to develop non-alcoholic fatty liver
disease (NAFLD) worldwide. NAFLD comprises different stadia going from isolated steatosis …

Akkermansia muciniphila ameliorates acetaminophen-induced liver injury by regulating gut microbial composition and metabolism

J Xia, L Lv, B Liu, S Wang, S Zhang, Z Wu… - Microbiology …, 2022 - Am Soc Microbiol
The gut microbiota drives individual sensitivity to excess acetaminophen (APAP)-mediated
hepatotoxicity. It has been reported that the bacterium Akkermansia muciniphila protects …

[HTML][HTML] Pediococcus pentosaceus, a future additive or probiotic candidate

S Jiang, L Cai, L Lv, L Li - Microbial Cell Factories, 2021 - Springer
Background Pediococcus pentosaceus, a promising strain of lactic acid bacteria (LAB), is
gradually attracting attention, leading to a rapid increase in experimental research. Due to …

The protective effects of live and pasteurized Akkermansia muciniphila and its extracellular vesicles against HFD/CCl4-induced liver injury

S Keshavarz Azizi Raftar, F Ashrafian… - Microbiology …, 2021 - Am Soc Microbiol
Akkermansia muciniphila, as a member of the gut microbiota, has been proposed as a next-
generation probiotic. Liver fibrosis is the main determinant of liver dysfunction and mortality …

Lactobacillus lactis and Pediococcus pentosaceus‐driven reprogramming of gut microbiome and metabolome ameliorates the progression of non‐alcoholic fatty …

JS Yu, GS Youn, J Choi, CH Kim… - Clinical and …, 2021 - Wiley Online Library
Background Although microbioa‐based therapies have shown putative effects on the
treatment of non‐alcoholic fatty liver disease (NAFLD), it is not clear how microbiota‐derived …

NOREVA: enhanced normalization and evaluation of time-course and multi-class metabolomic data

Q Yang, Y Wang, Y Zhang, F Li, W Xia… - Nucleic acids …, 2020 - academic.oup.com
Biological processes (like microbial growth & physiological response) are usually dynamic
and require the monitoring of metabolic variation at different time-points. Moreover, there is …

Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): focusing on the gut–liver axis

H Han, Y Jiang, M Wang, M Melaku, L Liu… - Critical reviews in …, 2023 - Taylor & Francis
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders
in humans, partly because it is closely related to metabolic disorders of the liver with …

[HTML][HTML] Lactobacillus attenuates progression of nonalcoholic fatty liver disease by lowering cholesterol and steatosis

NY Lee, MJ Shin, GS Youn, SJ Yoon… - Clinical and …, 2021 - ncbi.nlm.nih.gov
Methods The gut microbiome was analyzed via next-generation sequencing in healthy
people (n= 37) and NAFLD patients with elevated liver enzymes (n= 57). Six-week-old male …

[HTML][HTML] The role of the gut microbiome in liver cirrhosis treatment

NY Lee, KT Suk - International journal of molecular sciences, 2020 - mdpi.com
Liver cirrhosis is one of the most prevalent chronic liver diseases worldwide. In addition to
viral hepatitis, diseases such as steatohepatitis, autoimmune hepatitis, sclerosing …