Gout, a chronic inflammatory arthritis disease, is characterized by hyperuricemia and caused
by interactions between genetic, epigenetic, and metabolic factors. Acute gout symptoms are …

Hyperuricaemia (increased serum urate concentration) occurs mainly in higher primates,
including in humans, because of inactivation of the gene encoding uricase during primate …

Inflammasomes are a multi-protein platform forming a part of the innate immune system.
Inflammasomes are at standby status and can be activated when needed. Inflammasome …

Phellodendri Chinese Cortex has long been used to treat hyperuricemia and gout.
Berberine (BBR), its characteristic ingredient, has also been shown to be effective in …

Background and Purpose Gouty arthritis is characterized by an intense inflammatory
response to monosodium urate crystals (MSU), which induces severe pain. Current …

Gout is a disease with acute and/or chronic inflammation and tissue damage induced by the
precipitation of monosodium urate crystal (MSU) crystals in bone joints, kidneys, and …

Central nervous system infection can induce epilepsy that is often refractory to established
antiseizure drugs. Previous studies in the Theiler's murine encephalomyelitis virus (TMEV) …

Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related
quality of life, representing a progressively increasing public health problem. Flares can be …

With the worldwide epidemics of hyperuricemia and associated gout, the diseases with
purine metabolic disorders have become a serious threat to human public health …

Exopolysaccharides (EPSs) possess many bioactivities such as immune regulation,
antioxidant, anti-tumor and modulation of intestinal microbial balance but their direct effect …