Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is
characterized by high morbidity and low survival rates with limited therapeutic options …

Cell cycle regulation is orchestrated by a complex network of interactions between proteins,
enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation …

Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

As a phenolic acid compound, caffeic acid (CA) can be isolated from different sources such
as tea, wine and coffee. Caffeic acid phenethyl ester (CAPE) is naturally occurring derivative …

Drug resistance developed towards conventional therapy is one of the important reasons for
chemotherapy failure in cancer. The various underlying mechanism for drug resistance …

Cancer treatment with either standard chemotherapy or targeted agents often results in the
emergence of drug-refractory cell populations, ultimately leading to therapy failure. The …

Drug resistance is the main culprit of failure in cancer therapy that may lead to cancer
relapse. This resistance mostly originates from rare, but impactful presence of cancer stem …

Systemic therapy often results in the reduction of tumor size but rarely succeeds in
eradicating all cancer cells. Drug efflux, persistence of cancer stem cells (CSCs), epithelial …

Although many drugs/treatments are now available for most diseases, too often, resistance
to these treatments impedes complete therapeutic success. Acquired resistance is a major …

Despite many advances and optimization in colon cancer treatment, tumor recurrence and
metastases make the development of new therapies necessary. Colon cancer stem cells …