Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions
VL Villemagne, V Doré, SC Burnham… - Nature Reviews …, 2018 - nature.com
Most neurodegenerative disorders are associated with aggregated protein deposits. In the
case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular …
case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular …
Spreading of pathology in neurodegenerative diseases: a focus on human studies
J Brettschneider, KD Tredici, VMY Lee… - Nature Reviews …, 2015 - nature.com
The progression of many neurodegenerative diseases is thought to be driven by the
template-directed misfolding, seeded aggregation and cell–cell transmission of …
template-directed misfolding, seeded aggregation and cell–cell transmission of …
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease
See Sarazin et al.(doi: 10.1093/brain/aww041) for a scientific commentary on this article.
The advent of the positron emission tomography tracer 18 F-AV1451 provides the unique …
The advent of the positron emission tomography tracer 18 F-AV1451 provides the unique …
[HTML][HTML] CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER …
Introduction We studied whether fully automated Elecsys cerebrospinal fluid (CSF)
immunoassay results were concordant with positron emission tomography (PET) and …
immunoassay results were concordant with positron emission tomography (PET) and …
Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers
The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis
Importance Amyloid-β positron emission tomography (PET) imaging allows in vivo detection
of fibrillar plaques, a core neuropathological feature of Alzheimer disease (AD). Its …
of fibrillar plaques, a core neuropathological feature of Alzheimer disease (AD). Its …
Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer's disease: a PET substudy interim analysis
G Klein, P Delmar, N Voyle, S Rehal… - Alzheimer's research & …, 2019 - Springer
Background We previously investigated low doses (105 or 225 mg) of gantenerumab, a fully
human monoclonal antibody that binds and removes aggregated amyloid-β by Fc receptor …
human monoclonal antibody that binds and removes aggregated amyloid-β by Fc receptor …
Plasma phospholipids identify antecedent memory impairment in older adults
Alzheimer's disease causes a progressive dementia that currently affects over 35 million
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …
Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: phase 3 study
Background Evaluation of brain β‐amyloid by positron emission tomography (PET) imaging
can assist in the diagnosis of Alzheimer disease (AD) and other dementias. Methods Open …
can assist in the diagnosis of Alzheimer disease (AD) and other dementias. Methods Open …