[HTML][HTML] Genetic variation in the non-coding genome: Involvement of micro-RNAs and long non-coding RNAs in disease
It has been found that the majority of disease-associated genetic variants identified by
genome-wide association studies are located outside of protein-coding regions, where they …
genome-wide association studies are located outside of protein-coding regions, where they …
A survey of gene expression meta-analysis: methods and applications
D Toro-Domínguez, JA Villatoro-Garciá… - Briefings in …, 2021 - academic.oup.com
The increasing use of high-throughput gene expression quantification technologies over the
last two decades and the fact that most of the published studies are stored in public …
last two decades and the fact that most of the published studies are stored in public …
A practical guide to linking brain-wide gene expression and neuroimaging data
The recent availability of comprehensive, brain-wide gene expression atlases such as the
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …
Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex
DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
Comparative single-cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution
Enhanced cognitive function in humans is hypothesized to result from cortical expansion
and increased cellular diversity. However, the mechanisms that drive these phenotypic …
and increased cellular diversity. However, the mechanisms that drive these phenotypic …
De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability
Schizophrenia is a serious psychiatric disorder with a broadly undiscovered genetic
etiology. Recent studies of de novo mutations (DNMs) in schizophrenia and autism have …
etiology. Recent studies of de novo mutations (DNMs) in schizophrenia and autism have …
A transcriptional signature of hub connectivity in the mouse connectome
BD Fulcher, A Fornito - … of the National Academy of Sciences, 2016 - National Acad Sciences
Connectivity is not distributed evenly throughout the brain. Instead, it is concentrated on a
small number of highly connected neural elements that act as network hubs. Across different …
small number of highly connected neural elements that act as network hubs. Across different …
Guidance for RNA-seq co-expression network construction and analysis: safety in numbers
Motivation: RNA-seq co-expression analysis is in its infancy and reasonable practices
remain poorly defined. We assessed a variety of RNA-seq expression data to determine …
remain poorly defined. We assessed a variety of RNA-seq expression data to determine …
Pan-mitogenomics reveals the genetic basis of cytonuclear conflicts in citrus hybridization, domestication, and diversification
N Wang, C Li, L Kuang, X Wu, K Xie… - Proceedings of the …, 2022 - National Acad Sciences
Although interactions between the cytoplasmic and nuclear genomes occurred during
diversification of many plants, the evolutionary conflicts due to cytonuclear interactions are …
diversification of many plants, the evolutionary conflicts due to cytonuclear interactions are …
SigCom LINCS: data and metadata search engine for a million gene expression signatures
Millions of transcriptome samples were generated by the Library of Integrated Network-
based Cellular Signatures (LINCS) program. When these data are processed into …
based Cellular Signatures (LINCS) program. When these data are processed into …