The function of p53 is best understood in response to genotoxic stress, but increasing
evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis …

Fatty acid synthase (FAS) catalyzes the de novo synthesis of fatty acids. In the liver, FAS has
long been categorized as a housekeeping protein, producing fat for storage of energy when …

We generated mice deficient in Lon protease (LONP1), a major enzyme of the mitochondrial
quality control machinery. Homozygous deletion of Lonp1 causes early embryonic lethality …

Dysregulated lipid metabolism is a prominent feature of prostate cancer that is driven by
androgen receptor (AR) signaling. Here we used quantitative mass spectrometry to define …

The transcription factor SOX2 is an essential regulator of pluripotent stem cells and
promotes development and maintenance of squamous epithelia. We previously reported …

The neural stem cell niche is a key regulator participating in the maintenance, regeneration,
and repair of the brain. Within the niche neural stem cells (NSC) generate new neurons …

Introduction The human epidermal growth factor receptor 2 (HER2) is a validated
therapeutic target in breast cancer. Heterodimerization of HER2 with other HER family …

The relationship between cellular metabolism and the cell cycle machinery is by no means
unidirectional. The ability of a cell to enter the cell cycle critically depends on the availability …

The p53 family of transcription factors is essential to counteract tumour formation and
progression. Although previously this was exclusively associated with the ability of the p53 …

De novo lipogenesis is a highly regulated metabolic process, which is known to be activated
through transcriptional regulation of lipogenic genes, including fatty acid synthase (FASN) …