The primary causes of chronic kidney disease (CKD) in children differ from those of CKD in
adults. In the USA the most common diagnostic groups of renal disease that manifest before …

In the process of matrix assembly, multivalent extracellular matrix (ECM) proteins are
induced to self-associate and to interact with other ECM proteins to form fibrillar networks …

Results In 74 of 300 families (25%), we identified a causative mutation in one of 20 genes
known to cause steroid-resistant nephrotic syndrome. In 11 families (3.7%), we detected a …

The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular
basement membrane (BM) and the interstitial ECM is identified as a crucial component of …

The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …

Fibronectin (FN) is a multidomain protein with the ability to bind simultaneously to cell
surface receptors, collagen, proteoglycans, and other FN molecules. Many of these domains …

Recent expert guidelines recommend genetic testing for the diagnosis of Alport syndrome.
Here, we describe current best practice and likely future developments. In individuals with …

Whole-exome sequencing (WES) and de novo variant detection have proven a powerful
approach to gene discovery in complex neurodevelopmental disorders. We have completed …

In the past decade, our understanding of the role of podocytes in the function of the
glomerular filtration barrier, and of the role of podocyte injury in the pathogenesis of …

Biomarkers are measurable changes associated with the disease. Urine can reflect the
changes of the body while blood is under control of the homeostatic mechanisms; thus, urine …