G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved
in signal transmission, have recently emerged as crucial players in tumour growth and …

Concepts regarding the mechanisms by which drugs activate receptors to produce
physiological response have progressed beyond considering the re¬ ceptor as a simple on …

Endocrine‐paracrine cells of the prostate (also known as APUD or neuroendocrine cells)
constitute, in addition to the basal and exocrine secretory cells, a third population of highly …

BACKGROUND Information is presented on prostatic neuroendocrine cells and
neuroendocrine differentiation in prostatic carcinoma. The prognostic and therapeutic …

The prognostic significance of neuroendocrine differentiation in prostatic malignancy is
controversial, but the results of recent studies with markers such as chromogranin A and …

Although adrenomedullin (AM) previously has been identified in human tumors, its role has
remained elusive. Analysis by reverse transcriptase-polymerase chain reaction (RT-PCR) …

Over the past 20 years, abundant evidence has been collected to suggest that gastrin-
releasing peptide (GRP) and its receptors play an important role in the development of a …

This article describes the expected phenotypic behavior of all types of ligands in
constitutively active receptor systems and, in particular, the molecular mechanisms of …

Autocrine and paracrine signaling leading to stimulation of tumor cell growth is a common
theme in human cancers. In addition to polypeptide growth factors such as EGF family …

BACKGROUND Bombesin‐like peptides can function as autocrine or paracrine growth
factors and stimulate the growth of some cancer cells, including human prostate cancer …