Pioneer transcription factors initiating gene network changes
KS Zaret - Annual review of genetics, 2020 - annualreviews.org
Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA
sequence motifs that are exposed on the surface of a nucleosome and thus access silent …
sequence motifs that are exposed on the surface of a nucleosome and thus access silent …
Ten principles of heterochromatin formation and function
RC Allshire, HD Madhani - Nature reviews Molecular cell biology, 2018 - nature.com
Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …
particular genomic domains with specific functional properties. The capacity of …
Heterochromatin: guardian of the genome
A Janssen, SU Colmenares… - Annual review of cell and …, 2018 - annualreviews.org
Constitutive heterochromatin is a major component of the eukaryotic nucleus and is
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …
The interplay of epigenetic marks during stem cell differentiation and development
Y Atlasi, HG Stunnenberg - Nature Reviews Genetics, 2017 - nature.com
Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …
reshaped during early development and differentiation. Epigenetic modification of chromatin …
Cooperative binding of transcription factors orchestrates reprogramming
Summary Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency. To
gain a mechanistic understanding of their function, we mapped OSKM-binding, stage …
gain a mechanistic understanding of their function, we mapped OSKM-binding, stage …
H3K9me3-dependent heterochromatin: barrier to cell fate changes
Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
Epigenetic changes during aging and their reprogramming potential
AE Kane, DA Sinclair - Critical reviews in biochemistry and …, 2019 - Taylor & Francis
The aging process results in significant epigenetic changes at all levels of chromatin and
DNA organization. These include reduced global heterochromatin, nucleosome remodeling …
DNA organization. These include reduced global heterochromatin, nucleosome remodeling …
[HTML][HTML] Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation
Mammalian oocytes can reprogram somatic cells into a totipotent state enabling animal
cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT …
cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT …
Somatic cell nuclear transfer reprogramming: mechanisms and applications
Successful cloning of monkeys, the first non-human primate species, by somatic cell nuclear
transfer (SCNT) attracted worldwide attention earlier this year. Remarkably, it has taken …
transfer (SCNT) attracted worldwide attention earlier this year. Remarkably, it has taken …
Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions
Topological-associated domains (TADs) are thought to be relatively stable across cell types,
although some TAD reorganization has been observed during cellular differentiation …
although some TAD reorganization has been observed during cellular differentiation …