Central precocious puberty results from the premature activation of the hypothalamic-
pituitary-gonadal axis. It mimics physiological pubertal development, although at an …

The classic definition of precocious sexual maturation is the development of secondary
sexual characteristics before 8 years of age in girls and before 9 years of age in boys. It is …

Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain
challenging due to lack of standardization. The aim of this revision was to address the …

Precocious puberty is defined as the appearance of secondary sex characteristics before 8
years of age in girls and before 9 years of age in boys. Central precocious puberty (CPP) is …

Background Precocious puberty (PP) in girls is traditionally defined as the onset of breast
development before the age of 8 years. The specific biomarkers of premature thelarche (PT) …

Background A brief gonadotropin-releasing hormone analogues (GnRHa) stimulation test
which solely focused on LH 30-minute post-stimulation was considered to identify girls with …

Преждевременное половое развитие является актуальной проблемой детской
эндокринологии, характеризующейся клинической и патогенетической …

Context Nonprogressive premature thelarche (PT) is a self-limiting variant of early puberty,
while idiopathic central precocious puberty (ICPP) is a disorder that causes progressive …

Precocious puberty (PP) means the appearance of secondary sexual characters before the
age of eight years in girls and nine years in boys. Puberty is indicated in girls by the …

Purpose Precocious puberty refers to the development of secondary sex characteristics
before ages 8 and 9 years in girls and boys, respectively. Central precocious puberty (CPP) …