Roles of RIPK3 in necroptosis, cell signaling, and disease
MJ Morgan, YS Kim - Experimental & molecular medicine, 2022 - nature.com
Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …
An outline of necrosome triggers
T Vanden Berghe, B Hassannia… - Cellular and Molecular …, 2016 - Springer
Necroptosis was initially identified as a backup cell death program when apoptosis is
blocked. However, it is now recognized as a cellular defense mechanism against infections …
blocked. However, it is now recognized as a cellular defense mechanism against infections …
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
Inflammasome is an intracellular signaling complex of the innate immune system. Activation
of inflammasomes promotes the secretion of interleukin 1β (IL-1β) and IL-18 and triggers …
of inflammasomes promotes the secretion of interleukin 1β (IL-1β) and IL-18 and triggers …
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
Necroptosis is a type of programmed cell death with great significance in many pathological
processes. Tumour necrosis factor-α (TNF), a proinflammatory cytokine, is a prototypic …
processes. Tumour necrosis factor-α (TNF), a proinflammatory cytokine, is a prototypic …
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis
Receptor-interacting protein kinase 3 (RIP3)-regulated production of reactive oxygen
species (ROS) positively feeds back on tumour necrosis factor (TNF)-induced necroptosis, a …
species (ROS) positively feeds back on tumour necrosis factor (TNF)-induced necroptosis, a …
Distinct roles of RIP1–RIP3 hetero-and RIP3–RIP3 homo-interaction in mediating necroptosis
XN Wu, ZH Yang, XK Wang, Y Zhang, H Wan… - Cell Death & …, 2014 - nature.com
Necroptosis is mediated by a signaling complex called necrosome, containing receptor-
interacting protein (RIP) 1, RIP3, and mixed-lineage kinase domain-like (MLKL). It is known …
interacting protein (RIP) 1, RIP3, and mixed-lineage kinase domain-like (MLKL). It is known …
Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in …
Receptor interacting protein 3 (RIP3) is a protein kinase essential for TNF-induced
necroptosis. Phosphorylation on Ser-227 in human RIP3 (hRIP3) is required for its …
necroptosis. Phosphorylation on Ser-227 in human RIP3 (hRIP3) is required for its …
RIPK3 signaling and its role in the pathogenesis of cancers
S Liu, K Joshi, MF Denning, J Zhang - Cellular and Molecular Life …, 2021 - Springer
RIPK3 (receptor-interacting protein kinase 3) is a serine/threonine-protein kinase. As a key
component of necrosomes, RIPK3 is an essential mediator of inflammatory factors (such as …
component of necrosomes, RIPK3 is an essential mediator of inflammatory factors (such as …
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3
The auto-phosphorylation of murine receptor-interacting protein 3 (Rip3) on Thr 231 and Ser
232 in the necrosome is required to trigger necroptosis. However, how Rip3 phosphorylation …
232 in the necrosome is required to trigger necroptosis. However, how Rip3 phosphorylation …
Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy
Alternative autophagy is an autophagy-related protein 5 (Atg5)-independent type of
macroautophagy. Unc51-like kinase 1 (Ulk1) is an essential initiator not only for Atg5 …
macroautophagy. Unc51-like kinase 1 (Ulk1) is an essential initiator not only for Atg5 …