Transient interactions, which involve protein interactions that are formed and broken easily,
are important in many aspects of cellular function. Here we describe structural and functional …

The assumption that crystal contacts reflect natural macromolecular interactions makes a
basis for many studies in structural biology. However, the crystal state may correspond to a …

Electrostatic fields at the interface of the Ras binding domain of the protein Ral guanine
nucleotide dissociation stimulator (RalGDS) with the structurally analogous GTPases Ras …

This paper presents a discussion of existing methods for the analysis of macromolecular
interactions and complexes in crystal packing. Typical situations and conditions where …

Xenorhabdus nematophila secretes insecticidal proteins to kill its larval prey. We have
isolated an∼ 58-kDa GroEL homolog, secreted in the culture medium through outer …

Abstract The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by
broadly neutralizing antibodies and represents a promising vaccine target. However, MPER …

Abstract Changes in protein subdomains through alternative splicing often modify protein‐
protein interactions, altering biological processes. A relevant example is that of the stress …

Water networks in protein interfaces can complement direct interactions contributing
significantly to molecular recognition, function, and stability of protein association. Thus …

Alterations in cell cycle regulating proteins are a key characteristic in neoplastic proliferation
of lymphoblast cells in patients with Acute Lymphoblastic Leukemia (ALL). The aim of our …

Due to advances in structural biology, an increasing number of protein structures of
unknown function have been deposited in Protein Data Bank (PDB). These proteins are …