Collective gradient sensing and chemotaxis: modeling and recent developments

BA Camley - Journal of Physics: Condensed Matter, 2018 - iopscience.iop.org
Cells measure a vast variety of signals, from their environment's stiffness to chemical
concentrations and gradients; physical principles strongly limit how accurately they can do …

Physical limits on galvanotaxis

I Nwogbaga, AH Kim, BA Camley - Physical Review E, 2023 - APS
Eukaryotic cells can polarize and migrate in response to electric fields via “galvanotaxis,”
which aids wound healing. Experimental evidence suggests cells sense electric fields via …

Cell-to-cell variation sets a tissue-rheology–dependent bound on collective gradient sensing

BA Camley, WJ Rappel - Proceedings of the National …, 2017 - National Acad Sciences
When a single cell senses a chemical gradient and chemotaxes, stochastic receptor–ligand
binding can be a fundamental limit to the cell's accuracy. For clusters of cells responding to …

Trade-offs in concentration sensing in dynamic environments

A Kashyap, W Wang, BA Camley - Biophysical Journal, 2024 - cell.com
When cells measure concentrations of chemical signals, they may average multiple
measurements over time in order to reduce noise in their measurements. However, when …

Chemotaxis in uncertain environments: Hedging bets with multiple receptor types

A Hopkins, BA Camley - Physical Review Research, 2020 - APS
Eukaryotic cells are able to sense chemical gradients in a wide range of environments. We
show that, if a cell is exposed to a highly variable environment, it may gain chemotactic …

Leader cells in collective chemotaxis: Optimality and trade-offs

A Hopkins, BA Camley - Physical Review E, 2019 - APS
Clusters of cells can work together in order to follow a signal gradient, chemotaxing even
when single cells do not. Cells in different regions of collectively migrating neural crest …

Does nematic order allow groups of elongated cells to sense electric fields better?

K Kaiyrbekov, BA Camley - arXiv preprint arXiv:2404.04723, 2024 - arxiv.org
Collective response to external directional cues like electric fields plays a pivotal role in
processes such as tissue development, regeneration, and wound healing. In this study we …

Stochastic modelling suggests that an elevated superoxide anion-hydrogen peroxide ratio can drive extravascular phagocyte transmigration by lamellipodium …

S Kundu - Journal of Theoretical Biology, 2016 - Elsevier
Chemotaxis, integrates diverse intra-and inter-cellular molecular processes into a
purposeful patho-physiological response; the operatic rules of which, remain speculative …

Extracellular processing of molecular gradients by eukaryotic cells can improve gradient detection accuracy

I Segota, C Franck - Physical Review Letters, 2017 - APS
Eukaryotic cells sense molecular gradients by measuring spatial concentration variation
through the difference in the number of occupied receptors to which molecules can bind …

MODELING GALVANOTAXIS: PHYSICAL LIMITS OF SIGNAL SENSING & MORPHOLOGY EFFECTS

I Nwogbaga - 2024 - jscholarship.library.jhu.edu
Galvanotaxis--the migration of cells towards an electric field--is a natural phenomenon
prevalent during many biological processes such as wound healing and embryogenesis …