Collective gradient sensing and chemotaxis: modeling and recent developments
BA Camley - Journal of Physics: Condensed Matter, 2018 - iopscience.iop.org
Cells measure a vast variety of signals, from their environment's stiffness to chemical
concentrations and gradients; physical principles strongly limit how accurately they can do …
concentrations and gradients; physical principles strongly limit how accurately they can do …
Physical limits on galvanotaxis
I Nwogbaga, AH Kim, BA Camley - Physical Review E, 2023 - APS
Eukaryotic cells can polarize and migrate in response to electric fields via “galvanotaxis,”
which aids wound healing. Experimental evidence suggests cells sense electric fields via …
which aids wound healing. Experimental evidence suggests cells sense electric fields via …
Cell-to-cell variation sets a tissue-rheology–dependent bound on collective gradient sensing
When a single cell senses a chemical gradient and chemotaxes, stochastic receptor–ligand
binding can be a fundamental limit to the cell's accuracy. For clusters of cells responding to …
binding can be a fundamental limit to the cell's accuracy. For clusters of cells responding to …
Trade-offs in concentration sensing in dynamic environments
When cells measure concentrations of chemical signals, they may average multiple
measurements over time in order to reduce noise in their measurements. However, when …
measurements over time in order to reduce noise in their measurements. However, when …
Chemotaxis in uncertain environments: Hedging bets with multiple receptor types
Eukaryotic cells are able to sense chemical gradients in a wide range of environments. We
show that, if a cell is exposed to a highly variable environment, it may gain chemotactic …
show that, if a cell is exposed to a highly variable environment, it may gain chemotactic …
Leader cells in collective chemotaxis: Optimality and trade-offs
Clusters of cells can work together in order to follow a signal gradient, chemotaxing even
when single cells do not. Cells in different regions of collectively migrating neural crest …
when single cells do not. Cells in different regions of collectively migrating neural crest …
Does nematic order allow groups of elongated cells to sense electric fields better?
K Kaiyrbekov, BA Camley - arXiv preprint arXiv:2404.04723, 2024 - arxiv.org
Collective response to external directional cues like electric fields plays a pivotal role in
processes such as tissue development, regeneration, and wound healing. In this study we …
processes such as tissue development, regeneration, and wound healing. In this study we …
Stochastic modelling suggests that an elevated superoxide anion-hydrogen peroxide ratio can drive extravascular phagocyte transmigration by lamellipodium …
S Kundu - Journal of Theoretical Biology, 2016 - Elsevier
Chemotaxis, integrates diverse intra-and inter-cellular molecular processes into a
purposeful patho-physiological response; the operatic rules of which, remain speculative …
purposeful patho-physiological response; the operatic rules of which, remain speculative …
Extracellular processing of molecular gradients by eukaryotic cells can improve gradient detection accuracy
Eukaryotic cells sense molecular gradients by measuring spatial concentration variation
through the difference in the number of occupied receptors to which molecules can bind …
through the difference in the number of occupied receptors to which molecules can bind …
MODELING GALVANOTAXIS: PHYSICAL LIMITS OF SIGNAL SENSING & MORPHOLOGY EFFECTS
I Nwogbaga - 2024 - jscholarship.library.jhu.edu
Galvanotaxis--the migration of cells towards an electric field--is a natural phenomenon
prevalent during many biological processes such as wound healing and embryogenesis …
prevalent during many biological processes such as wound healing and embryogenesis …