Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene.
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …

Heterozygous loss-of-function mutations in progranulin (GRN) cause frontotemporal
dementia (FTD), a leading cause of early-onset dementia characterized clinically by …

Investigation of the neural mechanisms underlying social hierarchy requires a reliable and
effective behavioral test. The tube test is a simple and robust behavioral assay that we …

Background Heterozygous loss-of-function mutations in the progranulin (PGRN) gene
(GRN) cause a reduction in PGRN and lead to the development of frontotemporal dementia …

Parkinson's disease (PD) is defined by motor symptoms such as tremor at rest, bradykinesia,
postural instability, and stiffness. In addition to the classical motor defects that define PD, up …

Loss-of-function mutations in progranulin (GRN), a secreted glycoprotein expressed by
neurons and microglia, are a common autosomal dominant cause of frontotemporal …

Progranulin (PGRN) and transmembrane protein 106B (TMEM 106B) are important
lysosomal proteins implicated in frontotemporal lobar degeneration (FTLD) and other …

Frontotemporal dementia (FTD) is the most common neurodegenerative disorder in
individuals under age 60 and has no treatment or cure. Because many cases of FTD result …

Action selection is a capital feature of cognition that guides behavior in processes that range
from motor patterns to executive functions. Here, the ongoing actions need to be monitored …

Dominance hierarchy is a fundamental phenomenon in grouped animals and human
beings, however, the underlying regulatory mechanisms remain elusive. Here, we report that …