Relaxin family peptides and their receptors
RAD Bathgate, ML Halls… - Physiological …, 2013 - journals.physiology.org
There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous …
many roles in female and male reproduction, as a neuropeptide in the central nervous …
Ligand‐induced activation of the insulin receptor: a multi‐step process involving structural changes in both the ligand and the receptor
CW Ward, MC Lawrence - Bioessays, 2009 - Wiley Online Library
Current models of insulin binding to the insulin receptor (IR) propose (i) that there are two
binding sites on the surface of insulin which engage with two binding sites on the receptor …
binding sites on the surface of insulin which engage with two binding sites on the receptor …
[图书][B] Microwave heating as a tool for sustainable chemistry
NE Leadbeater - 2010 - taylorfrancis.com
Shorter reaction times, higher product yields, and enhanced selectivity are some of the
advantages microwave heating has over conventional methods, causing its use to transition …
advantages microwave heating has over conventional methods, causing its use to transition …
Cardiovascular effects of relaxin: from basic science to clinical therapy
Although substantial advances have been achieved in recent decades in the clinical
management of heart diseases, new therapies that provide better or additional efficacy with …
management of heart diseases, new therapies that provide better or additional efficacy with …
International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family …
ML Halls, RAD Bathgate, SW Sutton… - Pharmacological …, 2015 - ASPET
Relaxin, insulin-like peptide 3 (INSL3), relaxin-3, and INSL5 are the cognate ligands for the
relaxin family peptide (RXFP) receptors 1–4, respectively. RXFP1 activates pleiotropic …
relaxin family peptide (RXFP) receptors 1–4, respectively. RXFP1 activates pleiotropic …
Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus
S Ma, FE Olucha-Bordonau, MA Hossain… - Learning & …, 2009 - learnmem.cshlp.org
Hippocampal theta rhythm is thought to underlie learning and memory, and it is well
established that “pacemaker” neurons in medial septum (MS) modulate theta activity. Recent …
established that “pacemaker” neurons in medial septum (MS) modulate theta activity. Recent …
A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
Human gene-2 relaxin (H2 relaxin) is a pleiotropic hormone with powerful vasodilatory and
anti-fibrotic properties which has led to its clinical evaluation and provisional FDA approval …
anti-fibrotic properties which has led to its clinical evaluation and provisional FDA approval …
Relaxin family peptides: structure–activity relationship studies
The human relaxin peptide family consists of seven cystine‐rich peptides, four of which are
known to signal through relaxin family peptide receptors, RXFP1–4. As these peptides play …
known to signal through relaxin family peptide receptors, RXFP1–4. As these peptides play …
Relaxin-3/RXFP3 system regulates alcohol-seeking
PJ Ryan, HE Kastman, EV Krstew… - Proceedings of the …, 2013 - National Acad Sciences
Relapse and hazardous drinking represent the most difficult clinical problems in treating
patients with alcohol use disorders. Using a rat model of alcohol use and alcohol-seeking …
patients with alcohol use disorders. Using a rat model of alcohol use and alcohol-seeking …
Membrane receptors: structure and function of the relaxin family peptide receptors
RCK Kong, PJ Shilling, DK Lobb, PR Gooley… - Molecular and cellular …, 2010 - Elsevier
The receptors for members of the relaxin peptide family have only recently been discovered
and are G-protein-coupled receptors (GPCRs). Relaxin and insulin-like peptide 3 (INSL3) …
and are G-protein-coupled receptors (GPCRs). Relaxin and insulin-like peptide 3 (INSL3) …