This review is limited to discussion of synthesis and transport of lysosomal enzymes in
mammalian tissues. We focus on the processing of the oligosaccharides in lysosomal …

The lysosomal storage disorders constitute greater than 30 separate entities, the majority of
which result from the absence of one or more lysosomal enzymes. While many ofthese …

Lysosomes serve dual antagonistic functions in cells by mediating anabolic growth signaling
and the catabolic turnover of macromolecules. How these janus-faced activities are …

Dynamin is the mammalian homologue to the Drosophila shibire gene product. Mutations in
this 100-kD GTPase cause a pleiotropic defect in endocytosis. To further investigate its role …

Lysosomes are considered to be a terminal degradative compartment of the endocytic
pathway, into which transport is mostly unidirectional. However, specialized secretory …

Protein secretion from cells can take several forms. Secretion is constitutive if proteins are
secreted as fast as they are synthesized. In regulated secretion newly synthesized proteins …

Acidic noncaspase proteases-like cathepsins have been introduced as novel mediators of
apoptosis. A clear role for these proteases and the acidic endolysosomal compartment in …

Rab5 regulates endocytic membrane traffic by specifically recruiting cytosolic effector
proteins to their site of action on early endosomal membranes. We have characterized a …

Ceramide has been recognized as a common intracellular second messenger for various
cytokines, growth factors and other stimuli, such as CD95, chemotherapeutic drugs and …

Proopiomelanocortin (POMC), the precursor for melanotropic, corticotropic, and opioid
peptides such as alpha-melanocyte-stimulating hormone (alpha MSH), ACTH, and other …