Senescence is a leading cause of mortality, disability, and non‐communicable chronic
diseases in older adults. Mounting evidence indicates that the presence of cardiovascular …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Cerebrovascular CO2 reactivity (CVR) is often considered a bioassay of cerebrovascular
endothelial function. We recently introduced a test of cerebral shear‐mediated dilatation …

Cerebral hemodynamics, eg, cerebral blood flow, can be measured and quantified using
many different methods, with transcranial Doppler ultrasound (TCD) being one of the most …

Key points Brachial artery (BA) shear‐mediated dilatation is a widely used assessment of
vascular function with links to coronary artery health and cardiovascular risk. Cerebral …

Antibody use is a critical component of cardiovascular physiology research, and antibodies
are used to monitor protein abundance (immunoblot analysis) and protein expression and …

The problem of inadequate statistical reporting is long standing and widespread in the
biomedical literature, including in cardiovascular physiology. Although guidelines for …

Cocoa flavanols protect humans against vascular disease, as evidenced by improvements
in peripheral endothelial function, likely through nitric oxide signalling. Emerging evidence …

The regulation and defence of intracellular pH is essential for homeostasis. Indeed,
alterations in cerebrovascular acid–base balance directly affect cerebral blood flow (CBF) …

This study aimed to elucidate the effects of change in estrogen during the menstrual cycle
and menopause on shear-mediated dilation of the internal carotid artery (ICA), a potential …