Non-viral gene delivery vectors have lagged far behind viral ones in the current pipeline of
clinical trials of gene therapy nanomedicines. Even when non-viral nanovectors pose less …

Protein kinase CK2 is a small family of protein kinases that has been implicated in an
expanding array of biological processes. While it is widely accepted that CK2 is a regulatory …

Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by
genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine …

CFTR (cystic fibrosis transmembrane conductance regulator) is a member of the ATP-
binding cassette family of membrane proteins. Although almost all members of this family …

Background Lrrk2, a gene linked to Parkinson's disease, encodes a large scaffolding protein
with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes …

A major limitation of targeted cancer therapy is the rapid emergence of drug resistance,
which often arises through mutations at or downstream of the drug target or through intrinsic …

We previously reported that the combination of two safe proteostasis regulators, cysteamine
and epigallocatechin gallate (EGCG), can be used to improve deficient expression of the …

Cystic fibrosis (CF), the most common lethal monogenic disease in Caucasians, is
characterized by recurrent bacterial infections and colonization, mainly by Pseudomonas …

Cystic fibrosis (CF) is an inherited disorder caused by mutations in the gene encoding for the
cystic fibrosis transmembrane conductance regulator (CFTR) protein, an ATP-gated chloride …

Conformationally defective cystic fibrosis transmembrane conductance regulator (CFTR)
including rescued ΔF508-CFTR is rapidly eliminated from the plasma membrane (PM) even …