Background Mitochondria, the power plants of the cell, are known as a cross-road of
different cellular signaling pathways. These cytoplasmic double-membraned organelles play …

OBJECTIVE: Chronic inflammation and cellular senescence are intertwined in the
pathogenesis of premature aging, which is considered as an important contributing factor in …

Introduction P53 represents a key player in apoptosis-induction in cancers including
colorectal cancer (CRC) that ranks third worldwide in cancer prevalence as well as mortality …

SOX2 is crucial for the maintenance of the self-renewal capacity and multipotency of
mesenchymal stem cells (MSCs); however, the mechanism by which SOX2 is regulated …

Studies in the past have illuminated the potential benefit of resveratrol as an anticancer (pro-
apoptosis) and life-extending (pro-survival) compound. However, these two different effects …

Abstract Sirtuin 1 (SIRT1) exerts a neuroprotective effect on various neurologic diseases.
Here we investigated the protective functions of SIRT1 in astrocytes, which are the most …

Sirtfood is a new concept food that compounds diets that can target sirtuins (SIRTs). SIRTs
are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases and ADP …

Sirtuin1 (SIRT1), a type III protein deacetylase, is considered as a novel anti-aging protein
involved in regulation of cellular senescence/aging and inflammation. SIRT1 level and …

Chemoprevention is an approach to decrease cancer morbidity and mortality through
inhibition of carcinogenesis and prevention of disease progression. Although the trans …

The currently available chemotherapeutic regimens against gastric cancer are not very
effective, leading to high recurrence and poor survival. Resveratrol is a naturally occurring …