Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase …

MTE Maghraby, OMF Abou-Ghadir… - Bioorganic & medicinal …, 2020 - Elsevier
The present study includes design and synthesis of new molecular hybrids of 2-
methylthiobenzimidazole linked to various anti-inflammatory pharmacophores through 2 …

Prodigiosin from Serratia: Synthesis and potential applications

S Mnif, M Jardak, B Bouizgarne… - Asian Pacific Journal of …, 2022 - journals.lww.com
Prodigiosin is a red pigment with a pyrrolylpyrromethane skeleton. It is mainly produced by
bacterial strains belonging to the Serratia genus, but also by some other genera, including …

Synthesis, In Vivo Anti‐Inflammatory Activity, and Molecular Docking Studies of New Isatin Derivatives

R Jarapula, K Gangarapu, S Manda… - … journal of medicinal …, 2016 - Wiley Online Library
A novel synthesis of 2‐hydroxy‐N′‐(2‐oxoindolin‐3‐ylidene) benzohydrazide derivatives
was synthesized by the condensation of 2‐hydroxybenzohydrazide with substituted isatins …

In –silico molecular docking analysis of prodigiosin and cycloprodigiosin as COX-2 inhibitors

PS Krishna, K Vani, MR Prasad, B Samatha… - Springerplus, 2013 - Springer
Prodigiosin and cycloprodigiosin are tripyrrole red pigmented compounds with medical
importance for their anticancer property. In the present investigation, molecular docking …

Molecular targeting of prodigiosin against anti-inflammatory genes cyclooxygenase-1 and-2

J Anitha, A Muthusankar, S Viswanathan… - Process …, 2023 - Elsevier
The prodigiosin produced by the bacteria Serratia marcescens (SM) has been isolated and
optimized with the streak plate method from different natural sources, such as human urine …

ADMET, Molecular docking studies and binding energy calculations of Pyrimidine-2-Thiol Derivatives as Cox Inhibitors

DD Kodical, JP James, K Deepthi… - Research Journal of …, 2020 - indianjournals.com
Cyclooxygenase (COX), is an enzyme that is responsible for the formation of prostanoids,
including thromboxane and prostaglandins. Prostaglandins promote inflammation. Blockage …

In silico Prediction and Molecular Docking Studies of N-amidoalkylated Derivatives of 1, 3, 4-oxadiazole as COX-1 and COX-2 Potential Inhibitors

PV Zadorozhnii, VV Kiselev… - Research Journal of …, 2017 - indianjournals.com
In this paper, using the PASS and GUSAR software packages, we have prognosed the
analgesic activity and acute toxicity of N-amidoalkylated derivatives of 2-amino-5-aryl-1, 3, 4 …

Synthesis, analgesic and anti-inflammatory activities of novel mannich bases of benzimidazoles

N Kumar, CS Sharma, MS Ranawat, HP Singh… - Journal of …, 2015 - Springer
A series of novel mannich bases of 2-substituted benzimidazoles was synthesized by the
reaction of 2-substituted benzimidazoles with corresponding aldehyde and acetophenones …

Synthesis, anticancer evaluation, and docking studies of some novel azo chromene derivatives

K Bhuvaneswari, P Sivaguru… - Journal of the Chinese …, 2020 - Wiley Online Library
We have described a simple, convenient, and high‐yielding one‐pot synthesis of novel azo
chromene derivatives via a three‐component reaction of various azo aldehydes with …

In-silico Molecular Docking Studies of some Isolated Phytochemicals from Biophytum Veldkampii against Cyclooxygenase-II Enzyme and in vivo Anti-inflammatory …

N Bandaru, D Prasanth, AR Reddy… - Pharmacognosy …, 2021 - phcogres.com
Background: The current study estimate the anti-inflammatory activity of whole plant of
Biophytum veldkampii on carageenan induced inflammation on rats compiled by molecular …