Inorganic phosphate (Pi) plays a critical function in many tissues of the body: for example, as
part of the hydroxyapatite in the skeleton and as a substrate for ATP synthesis. Pi is the main …

Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …

FGF23 is a unique member of the fibroblast growth factor (FGF) family because it acts as a
hormone that derives from bone and regulates kidney functions, whereas most other family …

Elevated serum phosphate levels have been linked with vascular calcification and mortality
among dialysis patients. The relationship between phosphate and mortality has not been …

Appropriate levels of phosphate in the body are maintained by the coordinated regulation of
the bone-derived growth factor FGF23 and the membrane-bound protein Klotho. The …

In mammals, phosphate balance is maintained by influx and efflux via the intestines,
kidneys, bone, and soft tissue, which involves multiple sodium/phosphate (Na+/Pi) …

Inorganic phosphate (Pi) is an abundant element in the body and is essential for a wide
variety of key biological processes. It plays an essential role in cellular energy metabolism …

The renal handling of inorganic phosphate (Pi) is controlled not only by PTH, but also by
hitherto undetermined mechanisms dependent on phosphate intake. Recently, fibroblast …

Introduction Currently no evidence-based guideline exists for the approach to
hypophosphatemia in critically ill patients. Methods We performed a narrative review of the …

Optimal cellular function is dependent on maintenance of a normal serum phosphorus
concentration. Serum phosphorus concentration is affected by several determinants, the …