Salivary gland cancer (SGC) is immensely heterogeneous, both in terms of its physical
manifestation and its aggressiveness. Developing a novel diagnostic and prognostic …

Characteristics of the tumour that affect and predict the survival outcome of patients with
cancer are prognostic markers for cancer. In non-small cell lung carcinoma (NSCLC), stage …

Splicing abnormalities frequently occur in cancer. A key role as splice site choice regulator is
played by the members of the SR (Ser/Arg-rich) family of proteins. We recently demonstrated …

Hypoxia, a characteristic of most human solid tumors, is a major obstacle to successful
radiotherapy. While moderate acute hypoxia increases cell survival, chronic cycling hypoxia …

Lung cancer is the leading cause of cancer-related deaths worldwide. With a focus on
histology, there are two major subtypes: Non-small cell lung cancer (NSCLC)(the more …

Protease activated receptors (PAR) form a family of G‐protein coupled receptors (GPCR)
encoding their own ligands and uniquely activated via proteolytic cleavage. Although …

Introduction Apoptosis is a crucial pathway in tumor growth and metastatic development.
Apoptotic proteins regulate the underlying molecular cascades and are thought to modulate …

Lung cancer is a leading cause of cancer death worldwide. Several alterations in RNA
metabolism have been found in lung cancer cells; this suggests that RNA metabolism …

Background Bcl-2 promotes cell survival by inhibiting adapters needed for the activation and
cleavage of caspases thus blocking the proteolytic cascade that ultimately dismantles the …

Experimental evidence suggests that in lung cancer, development, progression and an
increased proliferation rate can be linked to apoptosis-related factors. The objective of this …