[HTML][HTML] Macrophages as tools and targets in cancer therapy
A Mantovani, P Allavena, F Marchesi… - Nature Reviews Drug …, 2022 - nature.com
Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …
A timeline of tumour-associated macrophage biology
L Cassetta, JW Pollard - Nature Reviews Cancer, 2023 - nature.com
Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …
populated by many immune cells, of which macrophages are among the most abundant …
CD4+ T cells in cancer
Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
Clinical relevance of tumour-associated macrophages
MJ Pittet, O Michielin, D Migliorini - Nature reviews Clinical oncology, 2022 - nature.com
In the past decade, substantial advances have been made in understanding the biology of
tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …
tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …
Dendritic cells as shepherds of T cell immunity in cancer
In cancer patients, dendritic cells (DCs) in tumor-draining lymph nodes can present antigens
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …
[HTML][HTML] Tumour-associated macrophages: versatile players in the tumour microenvironment
ZZ Ji, MKK Chan, ASW Chan, KT Leung… - Frontiers in Cell and …, 2023 - frontiersin.org
Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour
microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and …
microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and …
[HTML][HTML] Targeting tumor-associated macrophages for successful immunotherapy of ovarian carcinoma
I Truxova, D Cibula, R Spisek… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Epithelial ovarian cancer (EOC) is among the top five causes of cancer-related death in
women, largely reflecting early, prediagnosis dissemination of malignant cells to the …
women, largely reflecting early, prediagnosis dissemination of malignant cells to the …
[HTML][HTML] Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
A Ghasemi, A Martinez-Usatorre, L Li, M Hicham… - Nature Cancer, 2024 - nature.com
Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation,
trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested …
trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested …
[HTML][HTML] The generation, activation, and polarization of monocyte-derived macrophages in human malignancies
P Chaintreuil, E Kerreneur, M Bourgoin… - Frontiers in …, 2023 - frontiersin.org
Macrophages are immune cells that originate from embryogenesis or from the differentiation
of monocytes. They can adopt numerous phenotypes depending on their origin, tissue …
of monocytes. They can adopt numerous phenotypes depending on their origin, tissue …
[HTML][HTML] Advances in immunotherapeutics in pancreatic ductal adenocarcinoma
T Chouari, FS La Costa, N Merali, MD Jessel… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is the most common type of
pancreatic cancer, responsible for the majority of cases and ranking seventh as a leading …
pancreatic cancer, responsible for the majority of cases and ranking seventh as a leading …