Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons

PL Wantuch, DA Rosen - Trends in Immunology, 2023 - cell.com
Klebsiella pneumoniae is among the most common antibiotic-resistant pathogens causing
nosocomial infections. Additionally, it is a leading cause of neonatal sepsis and childhood …

Prevalence of hypervirulent and carbapenem-resistant Klebsiella pneumoniae under divergent evolutionary patterns

D Tian, X Liu, W Chen, Y Zhou, D Hu… - Emerging microbes & …, 2022 - Taylor & Francis
ABSTRACT K1/K2 hvKP strains acquire carbapenem-resistance plasmids, known as CR-
hvKp, and carbapenem-resistant Klebsiella pneumoniae (CRKP) strains obtain virulence …

Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?

Z Liang, Y Wang, Y Lai, J Zhang, L Yin, X Yu… - Frontiers in Cellular …, 2022 - frontiersin.org
Klebsiella pneumonia e (K. pneumoniae) is a typical gram-negative iatrogenic bacterium
that often causes bacteremia, pneumonia and urinary tract infection particularly among …

Design and fabrication of a vaccine candidate based on rOmpA from Klebsiella pneumoniae encapsulated in silk fibroin-sodium alginate nanoparticles against …

S Shahbazi, M Habibi, F Badmasti, S Sabzi… - International …, 2023 - Elsevier
The present study describes the design and fabrication of a novel vaccine candidate based
on the outer membrane protein A (rOmpA) from Klebsiella pneumoniae (K. pneumoniae) …

The Type VI Secretion System Contributes to the Invasiveness of Liver Abscess Caused by Klebsiella pneumoniae

H Wang, Y Guo, Z Liu, Z Chang - The Journal of Infectious …, 2023 - academic.oup.com
Background Klebsiella pneumoniae liver abscess (KPLA) with extrahepatic migratory
infections is defined as invasive KPLA (IKPLA). The type VI secretion system (T6SS) is …

[HTML][HTML] Vaccine value profile for Klebsiella pneumoniae

Z Dangor, N Benson, JA Berkley, J Bielicki, MW Bijsma… - Vaccine, 2024 - Elsevier
Klebsiella pneumoniae causes community-and healthcare-associated infections in children
and adults. Globally in 2019, an estimated 1.27 million (95% Uncertainty Interval [UI]: 0.91 …

Clinical and Molecular Characteristics and Antibacterial Strategies of Klebsiella pneumoniae in Pyogenic Infection

Z Yang, R Zhou, Y Chen, X Zhang, L Liu… - Microbiology …, 2023 - Am Soc Microbiol
Treatment of Klebsiella pneumoniae causing pyogenic infections is challenging. The clinical
and molecular characteristics of Klebsiella pneumoniae causing pyogenic infections are …

Challenges in development of vaccines directed toward antimicrobial resistant bacterial species

M Brazzoli, D Piccioli, F Marchetti - Human Vaccines & …, 2023 - Taylor & Francis
Antimicrobial resistance (AMR) is considered by WHO one of the top ten public health
threats. New control strategies involving concerted actions of both public and private sectors …

Immunostimulatory chimeric protein encapsulated in gelatin nanoparticles elicits protective immunity against Pseudomonas aeruginosa respiratory tract infection

M Parvaei, M Habibi, S Shahbazi, M Babaluei… - International Journal of …, 2024 - Elsevier
This study presents the design and fabrication of an innovative vaccine candidate targeting
Pseudomonas aeruginosa (P. aeruginosa). The vaccine consists of gelatin nanoparticles …

A New Live Auxotrophic Vaccine Induces Cross-Protection against Klebsiella pneumoniae Infections in Mice

M Moscoso, JA Vallejo, MP Cabral, P García… - Vaccines, 2022 - mdpi.com
The development of a whole-cell vaccine from bacteria auxotrophic for D-amino acids
present in the bacterial cell wall is considered a promising strategy for providing protection …