Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

[PDF][PDF] Mesenchymal stromal cell homing: mechanisms and strategies for improvement

M Ullah, DD Liu, AS Thakor - Iscience, 2019 - cell.com
Mesenchymal stromal cells (MSCs) have been widely investigated for their therapeutic
potential in regenerative medicine, owing to their ability to home damaged tissue and serve …

Manufacturing of primed mesenchymal stromal cells for therapy

JQ Yin, J Zhu, JA Ankrum - Nature biomedical engineering, 2019 - nature.com
Mesenchymal stromal cells (MSCs) for basic research and clinical applications are
manufactured and developed as unique cell products by many different manufacturers and …

Mesenchymal stem cells: immune evasive, not immune privileged

JA Ankrum, JF Ong, JM Karp - Nature biotechnology, 2014 - nature.com
The diverse immunomodulatory properties of mesenchymal stem/stromal cells (MSCs) may
be exploited for treatment of a multitude of inflammatory conditions. MSCs have long been …

[HTML][HTML] The current status of mesenchymal stromal cells: controversies, unresolved issues and some promising solutions to improve their therapeutic efficacy

D García-Bernal, M García-Arranz… - Frontiers in Cell and …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) currently constitute the most frequently used cell type in
advanced therapies with different purposes, most of which are related with inflammatory …

Recent progress of stem cell therapy in cancer treatment: molecular mechanisms and potential applications

DT Chu, TT Nguyen, NLB Tien, DK Tran, JH Jeong… - Cells, 2020 - mdpi.com
The insufficient and unspecific target of traditional therapeutic approaches in cancer
treatment often leads to therapy resistance and cancer recurrence. Over the past decades …

MSCs: delivery routes and engraftment, cell‐targeting strategies, and immune modulation

TJ Kean, P Lin, AI Caplan, JE Dennis - Stem cells international, 2013 - Wiley Online Library
Mesenchymal stem cells (MSCs) are currently being widely investigated both in the lab and
in clinical trials for multiple disease states. The differentiation, trophic, and …

[PDF][PDF] Mesenchymal stem cell homing: the devil is in the details

JM Karp, GSL Teo - Cell stem cell, 2009 - cell.com
The study of MSC trafficking is clinically relevant for minimally invasive cell therapy to
promote regeneration of damaged tissue, to treat inflammation, and to promote …

Recent advances in mesenchymal stem cell membrane-coated nanoparticles for enhanced drug delivery

M Wang, Y Xin, H Cao, W Li, Y Hua, TJ Webster… - Biomaterials …, 2021 - pubs.rsc.org
Studies of nanomedicine have achieved dramatic progress in recent decades. However, the
main challenges that traditional nanomedicine has to overcome include low accumulation at …

[PDF][PDF] Glycotherapy: new advances inspire a reemergence of glycans in medicine

JE Hudak, CR Bertozzi - Chemistry & biology, 2014 - cell.com
The beginning of the 20 th century marked the dawn of modern medicine with glycan-based
therapies at the forefront. However, glycans quickly became overshadowed as DNA-and …