Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

Transcription by RNA polymerase II (Pol II) is carried out by an elongation complex. We
previously reported an activated porcine Pol II elongation complex, EC*, encompassing the …

Chromatin is a highly dynamic structure that imparts structural organization to the genome
and regulates the gene expression underneath. The decade long research in deciphering …

The regulation of transcription by RNA polymerase II is closely intertwined with the
regulation of chromatin structure. A host of proteins required for the disassembly …

Set2-mediated methylation of histone H3 Lys36 (H3K36) is a mark associated with the
coding sequences of actively transcribed genes, but it has a negative role during …

The conserved, multifunctional Polymerase-Associated Factor 1 complex (Paf1C) regulates
all stages of the RNA polymerase (Pol) II transcription cycle. In this review, we examine a …

The Paf1 complex (Paf1C), composed of the proteins Paf1, Ctr9, Cdc73, Rtf1, and Leo1,
accompanies RNA polymerase II (pol II) from the promoter to the 3′ end formation site of …

Genetic and cell-based studies have implicated the PAF1 complex (PAF1C) in transcription-
associated events, but there has been no evidence showing a direct role in facilitating …

Chromatin remodelers are ATP-dependent enzymes that reorganize nucleosomes within all
eukaryotic genomes. Here we report a complex of the Chd1 remodeler bound to a …