The quest for an effective dengue vaccine has culminated in two approved vaccines and
another that has completed phase 3 clinical trials. However, shortcomings exist in each …

Antibody-dependent enhancement (ADE) of infectious disease is a phenomenon whereby
host antibodies increase the severity of an infection. It is well established in viral infections …

Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the
lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory …

Antibodies have been used to prevent or treat viral infections since the nineteenth century,
but the full potential to use passive immunization for infectious diseases has yet to be …

Flaviviruses are vector-borne RNA viruses, many of which are clinically relevant human viral
pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever …

Highlights•Molecular structures and predicated models of flaviviral NS proteins.•Recent
advance in antiviral development targeting NS proteins.•Inhibitors targeting NS4B entering …

The Flavivirus genus contains many important human pathogens, including dengue,
Japanese encephalitis (JE), tick-borne encephalitis (TBE), West Nile (WN), yellow fever (YF) …

Flaviviruses encode a conserved, membrane-associated nonstructural protein 1 (NS1) with
replication and immune evasion functions. The current knowledge of secreted NS1 (sNS1) …

Dengue virus infection can cause dengue hemorrhagic fever (DHF). Dengue NS1 is
multifunctional. The intracellular dimeric NS1 (iNS1) forms part of the viral replication …

Dengue is a mosquito-borne disease which causes significant public health concerns in
tropical and subtropical countries. Dengue virus (DENV) has evolved various strategies to …