Simple Summary Nephrotoxicity is the dose-limiting factor of cisplatin treatment.
Nephrotoxicity is characterized by reduced kidney function. Although an often-reversible …

Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a
biologically uncontrolled process, whereas RCD involves tightly structured signaling …

NF-κB proteins are a family of transcription factors that are of central importance in
inflammation and immunity. NF-κB also plays important roles in other processes, including …

Nephrotoxicity is one of the most important side effects and therapeutical limitations of
aminoglycoside antibiotics, especially gentamicin. Despite rigorous patient monitoring …

Gentamicin is an aminoglycoside antibiotic widely used against infections by Gram-negative
microorganisms. Nephrotoxicity is the main limitation to its therapeutic efficacy. Gentamicin …

The activation of NF-κB transcription factor is critical for a wide range of processes such as
immunity, inflammation, cell development, growth and survival. It is activated by a variety of …

Arteriosclerosis causes significant morbidity and mortality worldwide. Central to this process
is the development of subclinical non-atherosclerotic intimal lesions before the appearance …

Oxeiptosis is a recently identified reactive oxygen species (ROS)-sensitive, caspase
independent, non-inflammatory regulated cell death pathway. The activation of Kelch-like …

Nanoparticles (NPs) are increasingly used in a wide variety of applications and products;
however, NPs may affect stress response pathways and interact with proteins in biological …

It is now recognized that oxidative injury and mitochondrial dysfunction are responsible for
many clinical disorders with unmet needs, including ischemia–reperfusion injury …