Overview of microRNA biogenesis, mechanisms of actions, and circulation

J O'Brien, H Hayder, Y Zayed, C Peng - Frontiers in endocrinology, 2018 - frontiersin.org
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating
gene expression. The majority of miRNAs are transcribed from DNA sequences into primary …

The lipid composition of extracellular vesicles: applications in diagnostics and therapeutic delivery

S Ghadami, K Dellinger - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
Extracellular vesicles (EVs), including exosomes, with nanoscale sizes, biological origins,
various functions, and unique lipid and protein compositions have been introduced as …

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA–an ISEV position paper

B Mateescu, EJK Kowal, BWM Van Balkom… - Journal of …, 2017 - Taylor & Francis
The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has
been demonstrated in a multitude of different in vitro cell systems and in a variety of body …

Recent insights into the nutritional immunomodulation of cancer‐related microRNAs

TÖ Şahin, B Yılmaz, N Yeşilyurt, D Cicia… - Phytotherapy …, 2023 - Wiley Online Library
Cancer is the most common cause of death worldwide, following cardiovascular diseases.
Cancer is a multifactorial disease and many reasons such as physical, chemical, biological …

RETRACTED ARTICLE: exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7

H Zhang, T Deng, S Ge, Y Liu, M Bai, K Zhu, Q Fan, J Li… - Oncogene, 2019 - nature.com
Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing
incidence and poor prognosis. Adipose tissue is known to function in energy storage and …

Extracellular vesicles in cancer drug resistance: roles, mechanisms, and implications

Q Yang, J Xu, J Gu, H Shi, J Zhang, J Zhang… - Advanced …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are cell‐derived nanosized vesicles that mediate cell‐to‐cell
communication via transporting bioactive molecules and thus are critically involved in …

The roles of the Let-7 family of MicroRNAs in the regulation of cancer stemness

Y Ma, N Shen, MS Wicha, M Luo - Cells, 2021 - mdpi.com
Cancer has long been viewed as a disease of normal development gone awry. Cancer stem-
like cells (CSCs), also termed as tumor-initiating cells (TICs), are increasingly recognized as …

Plasma exosome microRNAs are indicative of breast cancer

BN Hannafon, YD Trigoso, CL Calloway, YD Zhao… - Breast cancer …, 2016 - Springer
Background microRNAs are promising candidate breast cancer biomarkers due to their
cancer-specific expression profiles. However, efforts to develop circulating breast cancer …

Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds

AA Farooqi, NN Desai, MZ Qureshi… - Biotechnology …, 2018 - Elsevier
A rapidly growing body of experimental evidence has begun to shed light on the wide
ranging molecular mechanisms which modulate intra-and inter-cellular communications. A …

Scalable production of extracellular vesicles and its therapeutic values: a review

CY Ng, LT Kee, ME Al-Masawa, QH Lee… - International Journal of …, 2022 - mdpi.com
Extracellular vesicles (EVs) are minute vesicles with lipid bilayer membranes. EVs are
secreted by cells for intercellular communication. Recently, EVs have received much …