Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote …

P Ferdinandy, DJ Hausenloy, G Heusch… - Pharmacological …, 2014 - ASPET
Pre-, post-, and remote conditioning of the myocardium are well described adaptive
responses that markedly enhance the ability of the heart to withstand a prolonged …

Interaction of cardiovascular nonmodifiable risk factors, comorbidities and comedications with ischemia/reperfusion injury and cardioprotection by pharmacological …

P Ferdinandy, I Andreadou, GF Baxter, HE Bøtker… - Pharmacological …, 2023 - ASPET
Preconditioning, postconditioning, and remote conditioning of the myocardium enhance the
ability of the heart to withstand a prolonged ischemia/reperfusion insult and the potential to …

[HTML][HTML] The structural basis for the binding of repaglinide to the pancreatic KATP channel

D Ding, M Wang, JX Wu, Y Kang, L Chen - Cell reports, 2019 - cell.com
Repaglinide (RPG) is a short-acting insulin secretagogue widely prescribed for the treatment
of type 2 diabetes. It boosts insulin secretion by inhibiting the pancreatic ATP-sensitive …

[HTML][HTML] Clinical significance of chronic myocardial ischemia in coronary artery disease patients

PC Rezende, FF Ribas, CV Serrano Jr… - Journal of thoracic …, 2019 - ncbi.nlm.nih.gov
Myocardial ischemia is considered the cornerstone of the treatment of patients with coronary
artery disease (CAD). Although the deleterious effects of myocardial infarction, the maximum …

Cardiovascular effects of dipeptidyl peptidase-4 inhibitors: from risk factors to clinical outcomes

AJ Scheen - Postgraduate medicine, 2013 - Taylor & Francis
Abstract Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) are oral incretin-based glucose-
lowering agents with proven efficacy and safety in the management of type 2 diabetes …

Vildagliptin: a review of its use in type 2 diabetes mellitus

GM Keating - Drugs, 2014 - Springer
The dipeptidyl peptidase-4 inhibitor vildagliptin (Galvus®) is approved for use as
monotherapy and combination therapy in type 2 diabetes mellitus. A fixed-dose combination …

Current Position of Gliclazide and Sulfonylureas in the Contemporary Treatment Paradigm for Type 2 Diabetes: A Scoping Review

I Sahin, O Bakiner, T Demir, R Sari, A Atmaca - Diabetes Therapy, 2024 - Springer
The increasing burden of type 2 diabetes (T2D), in relation to alarming rise in the
prevalence; challenges in the diagnosis, prevention, and treatment; as well as the …

Dipeptidyl peptidase‐4 inhibitors can minimize the hypoglycaemic burden and enhance safety in elderly people with diabetes

A Avogaro, A Dardano… - Diabetes, Obesity …, 2015 - Wiley Online Library
The prevalence of type 2 diabetes mellitus (T2DM) among elderly people is increasing.
Often associated with disabilities/comorbidities, T2DM lowers the chances of successful …

Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection

J Russell, EF Du Toit, JN Peart, HH Patel… - Cardiovascular …, 2017 - Springer
Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading cause
of death in diabetes mellitus (DM). In addition to eliciting cardiomyopathy, DM induces a …

Rosiglitazone does not show major hidden cardiotoxicity in models of ischemia/reperfusion but abolishes ischemic preconditioning-induced antiarrhythmic effects in …

BY Weber, GB Brenner, B Kiss, TG Gergely… - Pharmaceuticals, 2022 - mdpi.com
Clinical observations are highly inconsistent with the use of the antidiabetic rosiglitazone
regarding its associated increased risk of myocardial infarction. This may be due to its …