Worldwide prevalence of familial hypercholesterolemia: meta-analyses of 11 million subjects

SO Beheshti, CM Madsen, A Varbo… - Journal of the American …, 2020 - jacc.org
Background Despite the greater prevalence of familial hypercholesterolemia (FH) in
subjects with ischemic heart disease (IHD), premature IHD, and severe …

Pleiotropy in complex traits: challenges and strategies

N Solovieff, C Cotsapas, PH Lee, SM Purcell… - Nature Reviews …, 2013 - nature.com
Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …

Meta-analysis methods for genome-wide association studies and beyond

E Evangelou, JPA Ioannidis - Nature Reviews Genetics, 2013 - nature.com
Meta-analysis of genome-wide association studies (GWASs) has become a popular method
for discovering genetic risk variants. Here, we overview both widely applied and newer …

The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation

K Karg, M Burmeister, K Shedden… - Archives of general …, 2011 - jamanetwork.com
Objective: To perform a meta-analysis including all relevant studies exploring the interaction.
Data Sources: We identified studies published through November 2009 in PubMed. Study …

Flexible working and performance: A systematic review of the evidence for a business case

LM De Menezes, C Kelliher - International Journal of …, 2011 - Wiley Online Library
Interest in the outcomes of flexible working arrangements (FWAs) dates from the mid‐1970s,
when researchers attempted to assess the impact of flexitime on worker performance. This …

Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies

S Rodriguez, TR Gaunt, INM Day - American journal of …, 2009 - academic.oup.com
Mendelian randomization (MR) permits causal inference between exposures and a disease.
It can be compared with randomized controlled trials. Whereas in a randomized controlled …

Bayesian statistical methods for genetic association studies

M Stephens, DJ Balding - Nature Reviews Genetics, 2009 - nature.com
Bayesian statistical methods have recently made great inroads into many areas of science,
and this advance is now extending to the assessment of association between genetic …

Practical aspects of imputation-driven meta-analysis of genome-wide association studies

PIW De Bakker, MAR Ferreira, X Jia… - Human molecular …, 2008 - academic.oup.com
Motivated by the overwhelming success of genome-wide association studies, droves of
researchers are working vigorously to exchange and to combine genetic data to expediently …

[HTML][HTML] Replication in genome-wide association studies

P Kraft, E Zeggini, JPA Ioannidis - … science: a review journal of the …, 2009 - ncbi.nlm.nih.gov
Replication helps ensure that a genotype-phenotype association observed in a genome-
wide association (GWA) study represents a credible association and is not a chance finding …

[HTML][HTML] Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression

E Vassos, DA Collier, S Fazel - Molecular psychiatry, 2014 - nature.com
A large number of candidate gene studies for aggression and violence have been
conducted. Successful identification of associations between genetic markers and …