Mammals have evolved a remarkable diversity of ageing rates. Within the single order of
Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats …

Over 50 years of cancer research has resulted in the generation of massive amounts of
information, but relatively little progress has been made in the treatment of patients with solid …

With a world population living longer as well as marked disparities in life expectancy,
understanding the determinants of longevity is one of the priority research agendas in 21st …

Subterranean mammals spend their lives in dark, unventilated environments that are rich in
carbon dioxide and ammonia and low in oxygen. Many of these animals are also long-lived …

The naked mole-rat (Heterocephalus glaber) is a subterranean eusocial rodent with a
markedly long lifespan and resistance to tumorigenesis. Multiple data implicate modulation …

Despite intensive research, no satisfactory therapeutic options have been found for aging
and age-related diseases. The British scientist Leslie Orgel stated that evolution is cleverer …

Reactive oxygen species (ROS) are generated spontaneously in all organisms and cause
oxidative damage to biomolecules when present in excess. Accumulated oxidative damage …

The biology of aging is challenging to study, particularly in humans. As a result, model
organisms are used to approximate the physiological context of aging in humans. However …

The blind subterranean mole rat Spalax shows a remarkable tolerance to hypoxia, cancer-
resistance and longevity. Unravelling the genomic basis of these adaptations will be …

Oxygen is one of the important substances for the survival of most life systems on the earth,
and plateau and underground burrow systems are two typical hypoxic environments. Small …