Viral subversion of the cell polarity regulator Scribble

A Javorsky, PO Humbert… - Biochemical Society …, 2023 - portlandpress.com
Scribble is a scaffolding protein that regulates key events such as cell polarity,
tumorigenesis and neuronal signalling. Scribble belongs to the LAP family which comprise …

[HTML][HTML] Efficient green synthesis of hydrazide derivatives using L-proline: Structural characterization, anticancer activity, and molecular docking studies

SM Gomha, TZ Abolibda, AH Alruwaili, B Farag… - Catalysts, 2024 - mdpi.com
Green synthesis using L-proline as an organocatalyst is crucial due to its reusability, mild
conditions, clean reactions, easy workup, high purity, short reaction times, and high yields …

Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T‐cell lymphotrophic virus‐1 (HTLV‐1) Tax1 PBM

A Javorsky, JC Maddumage, ERR Mackie… - The FEBS …, 2023 - Wiley Online Library
Scribble (Scrib) is a highly conserved cell polarity regulator that harbours potent tumour
suppressor activity and plays an important role in cell migration. Dysregulation of polarity is …

[HTML][HTML] Dual specificity PDZ-and 14-3-3-binding motifs: a structural and interactomics study

G Gogl, P Jane, C Caillet-Saguy, C Kostmann, G Bich… - Structure, 2020 - cell.com
Protein-protein interaction motifs are often alterable by post-translational modifications. For
example, 19% of predicted human PDZ domain-binding motifs (PBMs) have been …

Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1

EM Thüring, C Hartmann, JC Maddumage… - Communications …, 2023 - nature.com
Scribble (Scrib) is a multidomain polarity protein and member of the leucine-rich repeat and
PDZ domain (LAP) protein family. A loss of Scrib expression is associated with disturbed …

Structural basis of the avian influenza NS1 protein interactions with the cell polarity regulator scribble

A Javorsky, PO Humbert, M Kvansakul - Viruses, 2022 - mdpi.com
Scribble is a highly conserved regulator of cell polarity, a process that enables the
generation of asymmetry at the cellular and tissue level in higher organisms. Scribble acts in …

Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling

A Javorsky, PO Humbert, M Kvansakul - Biochemical Journal, 2022 - portlandpress.com
The Scribble (Scrib) protein is a conserved cell polarity regulator with anti-tumorigenic
properties. Viruses like the Tick-born encephalitis virus (TBEV) target Scribble to establish a …

Scribble scrambles parathyroid hormone receptor interactions to regulate phosphate and vitamin D homeostasis

BZ Stewart, T Mamonova… - Proceedings of the …, 2023 - National Acad Sciences
G protein-coupled receptors, including PTHR, are pivotal for controlling metabolic processes
ranging from serum phosphate and vitamin D levels to glucose uptake, and cytoplasmic …

Structural basis of the human Scribble–Vangl2 association in health and disease

JY How, RK Stephens, KYB Lim… - Biochemical …, 2021 - portlandpress.com
Scribble is a critical cell polarity regulator that has been shown to work as either an
oncogene or tumor suppressor in a context dependent manner, and also impacts cell …

MotSASi: Functional short linear motifs (SLiMs) prediction based on genomic single nucleotide variants and structural data

M Martín, FG Brunello, CP Modenutti, JP Nicola… - Biochimie, 2022 - Elsevier
Short linear motifs (SLiMs) are key to cell physiology mediating reversible protein-protein
interactions. Precise identification of SLiMs remains a challenge, being the main drawback …