Viral subversion of the cell polarity regulator Scribble
A Javorsky, PO Humbert… - Biochemical Society …, 2023 - portlandpress.com
Scribble is a scaffolding protein that regulates key events such as cell polarity,
tumorigenesis and neuronal signalling. Scribble belongs to the LAP family which comprise …
tumorigenesis and neuronal signalling. Scribble belongs to the LAP family which comprise …
[HTML][HTML] Efficient green synthesis of hydrazide derivatives using L-proline: Structural characterization, anticancer activity, and molecular docking studies
Green synthesis using L-proline as an organocatalyst is crucial due to its reusability, mild
conditions, clean reactions, easy workup, high purity, short reaction times, and high yields …
conditions, clean reactions, easy workup, high purity, short reaction times, and high yields …
Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T‐cell lymphotrophic virus‐1 (HTLV‐1) Tax1 PBM
Scribble (Scrib) is a highly conserved cell polarity regulator that harbours potent tumour
suppressor activity and plays an important role in cell migration. Dysregulation of polarity is …
suppressor activity and plays an important role in cell migration. Dysregulation of polarity is …
[HTML][HTML] Dual specificity PDZ-and 14-3-3-binding motifs: a structural and interactomics study
Protein-protein interaction motifs are often alterable by post-translational modifications. For
example, 19% of predicted human PDZ domain-binding motifs (PBMs) have been …
example, 19% of predicted human PDZ domain-binding motifs (PBMs) have been …
Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1
EM Thüring, C Hartmann, JC Maddumage… - Communications …, 2023 - nature.com
Scribble (Scrib) is a multidomain polarity protein and member of the leucine-rich repeat and
PDZ domain (LAP) protein family. A loss of Scrib expression is associated with disturbed …
PDZ domain (LAP) protein family. A loss of Scrib expression is associated with disturbed …
Structural basis of the avian influenza NS1 protein interactions with the cell polarity regulator scribble
Scribble is a highly conserved regulator of cell polarity, a process that enables the
generation of asymmetry at the cellular and tissue level in higher organisms. Scribble acts in …
generation of asymmetry at the cellular and tissue level in higher organisms. Scribble acts in …
Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling
The Scribble (Scrib) protein is a conserved cell polarity regulator with anti-tumorigenic
properties. Viruses like the Tick-born encephalitis virus (TBEV) target Scribble to establish a …
properties. Viruses like the Tick-born encephalitis virus (TBEV) target Scribble to establish a …
Scribble scrambles parathyroid hormone receptor interactions to regulate phosphate and vitamin D homeostasis
BZ Stewart, T Mamonova… - Proceedings of the …, 2023 - National Acad Sciences
G protein-coupled receptors, including PTHR, are pivotal for controlling metabolic processes
ranging from serum phosphate and vitamin D levels to glucose uptake, and cytoplasmic …
ranging from serum phosphate and vitamin D levels to glucose uptake, and cytoplasmic …
Structural basis of the human Scribble–Vangl2 association in health and disease
JY How, RK Stephens, KYB Lim… - Biochemical …, 2021 - portlandpress.com
Scribble is a critical cell polarity regulator that has been shown to work as either an
oncogene or tumor suppressor in a context dependent manner, and also impacts cell …
oncogene or tumor suppressor in a context dependent manner, and also impacts cell …
MotSASi: Functional short linear motifs (SLiMs) prediction based on genomic single nucleotide variants and structural data
Short linear motifs (SLiMs) are key to cell physiology mediating reversible protein-protein
interactions. Precise identification of SLiMs remains a challenge, being the main drawback …
interactions. Precise identification of SLiMs remains a challenge, being the main drawback …