Bio-production of lactobionic acid: current status, applications and future prospects
Lactobionic acid has appeared on the commercial scene as a versatile polyhydroxy acid
with numerous promising applications in the food, medicine, pharmaceutical, cosmetics and …
with numerous promising applications in the food, medicine, pharmaceutical, cosmetics and …
Galectin-1: a traditionally immunosuppressive protein displays context-dependent capacities
X Yu, J Qian, L Ding, S Yin, L Zhou… - International Journal of …, 2023 - mdpi.com
Galectin–Carbohydrate interactions are indispensable to pathogen recognition and immune
response. Galectin-1, a ubiquitously expressed 14-kDa protein with an evolutionarily …
response. Galectin-1, a ubiquitously expressed 14-kDa protein with an evolutionarily …
Targeting galectin-1 overcomes breast cancer-associated immunosuppression and prevents metastatic disease
T Dalotto-Moreno, DO Croci, JP Cerliani… - Cancer research, 2013 - AACR
Abstract Galectin-1 (Gal1), an evolutionarily conserved glycan-binding protein, contributes to
the creation of an immunosuppressed microenvironment at sites of tumor growth. In spite of …
the creation of an immunosuppressed microenvironment at sites of tumor growth. In spite of …
High expression of Galectin‐1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic …
Galectin‐1 is implicated in making tumor cells immune privileged, in part by regulating the
survival of infiltrating T cells. Galectin‐1 is strongly expressed in activated pancreatic stellate …
survival of infiltrating T cells. Galectin‐1 is strongly expressed in activated pancreatic stellate …
Serum galectin-2,-4, and-8 are greatly increased in colon and breast cancer patients and promote cancer cell adhesion to blood vascular endothelium
H Barrow, X Guo, HH Wandall, JW Pedersen, B Fu… - Clinical cancer …, 2011 - AACR
Purpose: Adhesion of disseminating tumor cells to the blood vascular endothelium is a
pivotal step in metastasis. Previous investigations have shown that galectin-3 concentrations …
pivotal step in metastasis. Previous investigations have shown that galectin-3 concentrations …
Polymeric biomaterial-inspired cell surface modulation for the development of novel anticancer therapeutics
Immune cell-based therapies are a rapidly emerging class of new medicines that directly
treat and prevent targeted cancer. However multiple biological barriers impede the activity of …
treat and prevent targeted cancer. However multiple biological barriers impede the activity of …
Galectin-1 research in T cell immunity: past, present and future
F Cedeno-Laurent, CJ Dimitroff - Clinical immunology, 2012 - Elsevier
Galectin-1 (Gal-1) is one of 15 evolutionarily conserved ß-galactoside-binding proteins that
display biologically-diverse activities in pathogenesis of inflammation and cancer. Gal-1 is …
display biologically-diverse activities in pathogenesis of inflammation and cancer. Gal-1 is …
Immunosuppressive roles of galectin-1 in the tumor microenvironment
Evasion of immune surveillance is an accepted hallmark of tumor progression. The
production of immune suppressive mediators by tumor cells is one of the major mechanisms …
production of immune suppressive mediators by tumor cells is one of the major mechanisms …
Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment
The microenvironment of a tumor is a highly complex milieu, primarily characterized by
immunosuppression, abnormal angiogenesis, and hypoxic regions. These features promote …
immunosuppression, abnormal angiogenesis, and hypoxic regions. These features promote …
Galectin-9 in tumor biology: a jack of multiple trades
Galectin family members have been shown to exert multiple roles in the context of tumor
biology. Several recent findings support a similar multi-faceted role for galectin-9. Galectin-9 …
biology. Several recent findings support a similar multi-faceted role for galectin-9. Galectin-9 …