Timeless in animal circadian clocks and beyond

YD Cai, JC Chiu - The FEBS journal, 2022 - Wiley Online Library
TIMELESS (TIM) was first identified as a molecular cog in the Drosophila circadian clock.
Almost three decades of investigations have resulted in an insightful model describing the …

Integration of photoperiodic and temperature cues by the circadian clock to regulate insect seasonal adaptations

S Hidalgo, JC Chiu - Journal of Comparative Physiology A, 2024 - Springer
Organisms adapt to unfavorable seasonal conditions to survive. These seasonal
adaptations rely on the correct interpretation of environmental cues such as photoperiod …

Molecular basis of flowering under natural long-day conditions in Arabidopsis

YH Song, A Kubota, MS Kwon, MF Covington, N Lee… - Nature plants, 2018 - nature.com
Plants sense light and temperature changes to regulate flowering time. Here, we show that
expression of the Arabidopsis florigen gene, FLOWERING LOCUS T (FT), peaks in the …

Seasonal cues act through the circadian clock and pigment-dispersing factor to control EYES ABSENT and downstream physiological changes

S Hidalgo, M Anguiano, CA Tabuloc, JC Chiu - Current Biology, 2023 - cell.com
Organisms adapt to seasonal changes in photoperiod and temperature to survive; however,
the mechanisms by which these signals are integrated in the brain to alter seasonal biology …

Thermosensitive alternative splicing senses and mediates temperature adaptation in Drosophila

A Martin Anduaga, N Evantal, IL Patop, O Bartok… - Elife, 2019 - elifesciences.org
Circadian rhythms are generated by the cyclic transcription, translation, and degradation of
clock gene products, including timeless (tim), but how the circadian clock senses and adapts …

Regulation of feeding dynamics by the circadian clock, light and sex in an adult nocturnal insect

E Force, MBC Sokolowski, C Suray… - Frontiers in …, 2024 - frontiersin.org
Animals invest crucial resources in foraging to support development, sustenance, and
reproduction. Foraging and feeding behaviors are rhythmically expressed by most insects …

Genome-wide characterization of alternative splicing events and their responses to cold stress in tilapia

BJ Li, ZX Zhu, H Qin, ZN Meng, HR Lin, JH Xia - Frontiers in genetics, 2020 - frontiersin.org
Alternative splicing (AS) is an important post-transcriptional regulatory mechanism for cells
to generate transcript variability and proteome diversity. No systematic investigation of AS …

One Actor, Multiple Roles: The Performances of Cryptochrome in Drosophila

M Damulewicz, GM Mazzotta - Frontiers in physiology, 2020 - frontiersin.org
Cryptochromes (CRYs) are flavoproteins that are sensitive to blue light, first identified in
Arabidopsis and then in Drosophila and mice. They are evolutionarily conserved and play …

Roles of peripheral clocks: lessons from the fly

E Yildirim, R Curtis, DS Hwangbo - FEBS letters, 2022 - Wiley Online Library
To adapt to and anticipate rhythmic changes in the environment such as daily light–dark and
temperature cycles, internal timekeeping mechanisms called biological clocks evolved in a …

Peripheral Sensory Organs Contribute to Temperature Synchronization of the Circadian Clock in Drosophila melanogaster

R George, R Stanewsky - Frontiers in Physiology, 2021 - frontiersin.org
Circadian clocks are cell-autonomous endogenous oscillators, generated and maintained
by self-sustained 24-h rhythms of clock gene expression. In the fruit fly Drosophila …