[HTML][HTML] DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities
Y Abuetabh, HH Wu, C Chai, H Al Yousef… - … & molecular medicine, 2022 - nature.com
Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …
[HTML][HTML] EBNA1 Upregulates P53-Inhibiting Genes in Burkitt's Lymphoma Cell Line
SMA Hashemi, A Moradi, SY Hosseini… - … of Biochemistry & …, 2023 - ncbi.nlm.nih.gov
Background: Suppression of p53 is an important mechanism in Epstein-Barr virus associate-
tumors and described as EBNA1-USP7 which is a key axis in p53 suppression. Thus, in this …
tumors and described as EBNA1-USP7 which is a key axis in p53 suppression. Thus, in this …
[HTML][HTML] Impact of Cerium Oxide Nanoparticles on Metabolic, Apoptotic, Autophagic and Antioxidant Changes in Doxorubicin-Induced Cardiomyopathy: Possible …
SEEM Elmorshdy, GA Shaker, ZH Eldken… - … of Biochemistry & …, 2023 - ncbi.nlm.nih.gov
Background: In the current study, the effects of cerium oxide nanoparticles (nanocerium; NC)
on doxorubicin (DOX)-induced cardiomyopathy and its possible underlying mechanisms …
on doxorubicin (DOX)-induced cardiomyopathy and its possible underlying mechanisms …
[HTML][HTML] Protective Effects of Zingerone on Oxidative Stress in Doxorubicin-Induced Rat Hepatotoxicity
R Motamedi, S Aminzadeh, MJ Khodayar… - … of Biochemistry & …, 2024 - ncbi.nlm.nih.gov
Background: Doxorubicin, a commonly utilized anthracycline antibiotic and
chemotherapeutic agent, has been associated with hepatotoxicity as an adverse effect. This …
chemotherapeutic agent, has been associated with hepatotoxicity as an adverse effect. This …
[HTML][HTML] Detection of Methylene Tetrahydrofolate Reductase (MTHFR C677T) Mutation among Acute Lymphoblastic Leukemia in Sudanese Patients
WA Mohieldeen, A Ahmed, YM Elmosaad… - … of Biochemistry & …, 2023 - ncbi.nlm.nih.gov
Background: A genetic polymorphism that causes abnormal folate metabolism may lead to
genomic instability and increase susceptibility to malignancies such as Acute Lymphoblastic …
genomic instability and increase susceptibility to malignancies such as Acute Lymphoblastic …
[HTML][HTML] 靶向p53-MDM2 的抗肿瘤小分子抑制剂的研究进展
丁涵静， 胡美纯 - Advances in Clinical Medicine, 2023 - hanspub.org
p53 能够调控细胞周期, 诱导细胞凋亡和DNA 修复, 被称为“抑癌蛋白”. p53
的功能失调通常会引起遗传不稳定性, 促进肿瘤发生. MDM2 是p53 最重要的负反馈调节因子之 …
的功能失调通常会引起遗传不稳定性, 促进肿瘤发生. MDM2 是p53 最重要的负反馈调节因子之 …
Inhibition of MDM2 Using Idasanutlin (RG-7388) enhances the Chemo-sensitivity of B-ALL Cells to Daunorubicin
H Boustani, N Abbasi, A Ghotaslou… - Iranian Journal of …, 2023 - publish.kne-publishing.com
Background: Although significant advances have been made in the treatment of cancer, a
significant number of patients with acute lymphoblastic leukemia (ALL) show resistance to …
significant number of patients with acute lymphoblastic leukemia (ALL) show resistance to …