The histone methyltransferase Enhancer of Zeste Homologue 2 (EZH2), a component of the
polycomb group complex, is vital for stem cell development, including hematopoiesis. Its …

The orchestrated organization of epigenetic factors that control chromatin dynamism,
including DNA methylation, histone marks, non-coding RNAs (ncRNAs) and chromatin …

In eukaryotes, post-translational modification of histones is critical for regulation of chromatin
structure and gene expression. EZH2 is the catalytic subunit of the polycomb repressive …

Recent studies have thoroughly described genome-wide expression patterns defining
molecular subtypes of pancreatic ductal adenocarcinoma (PDAC), with different prognostic …

Changes of histone modification status at critical lineage-specifying gene loci in multipotent
precursors can influence cell fate commitment. The contribution of these epigenetic …

PRC2 is a therapeutic target for several types of cancers currently undergoing clinical trials.
Its activity is regulated by a positive feedback loop whereby its terminal enzymatic product …

EZH2 is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2) which catalyzes
methylation of histone H3 at lysine 27 (H3K27me) and mediates gene silencing of target …

Enhancer of zeste homolog 2 (EZH2)-mediated trimethylation of histone 3 lysine 27
(H3K27Me3) is critical for immune regulation. However, evidence is lacking to address the …

The biological processes controlling human growth are diverse, complex and poorly
understood. Genetic factors are important and human height has been shown to be a highly …

The outbreak of corona virus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
spreading globally and quickly, leading to emerging health issues. SARS-CoV-2 enters into …