An evidence-based approach to the prescription opioid epidemic in orthopedic surgery
EM Soffin, SA Waldman, RJ Stack… - Anesthesia & …, 2017 - journals.lww.com
Orthopedic surgery is associated with significant perioperative pain. Providing adequate
analgesia is a critical component of patient care and opioids play a vital role in the acute …
analgesia is a critical component of patient care and opioids play a vital role in the acute …
Perioperative opioids, the opioid crisis, and the anesthesiologist
Perioperative Opioids, the Opioid Crisis, and the Anesthesiologist | Anesthesiology | American
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Wide variation and overprescription of opioids after elective surgery
CA Thiels, SS Anderson, DS Ubl, KT Hanson… - Annals of …, 2017 - journals.lww.com
Objective: We aimed to identify opioid prescribing practices across surgical specialties and
institutions. Background: In an effort to minimize the contribution of prescription narcotics to …
institutions. Background: In an effort to minimize the contribution of prescription narcotics to …
Results of a prospective, multicenter initiative aimed at developing opioid-prescribing guidelines after surgery
CA Thiels, DS Ubl, KJ Yost, SC Dowdy… - Annals of …, 2018 - journals.lww.com
Objective: The aim of this study was to conduct a prospective, multicenter survey of patients
regarding postoperative opioid use to inform development of standardized, evidence-based …
regarding postoperative opioid use to inform development of standardized, evidence-based …
Prevalence of preoperative opioid use and characteristics associated with opioid use among patients presenting for surgery
Importance Patterns of preoperative opioid use are not well characterized across different
surgical services, and studies in this patient population have lacked important self-reported …
surgical services, and studies in this patient population have lacked important self-reported …
Effect of preoperative opioid exposure on healthcare utilization and expenditures following elective abdominal surgery
Objective: To examine the extent to which preoperative opioid use is correlated with
healthcare utilization and costs following elective surgical procedures. Summary …
healthcare utilization and costs following elective surgical procedures. Summary …
Morphine tolerance is attenuated in germfree mice and reversed by probiotics, implicating the role of gut microbiome
L Zhang, J Meng, Y Ban, R Jalodia… - Proceedings of the …, 2019 - National Acad Sciences
Prolonged exposure to opioids results in analgesic tolerance, drug overdose, and death.
The mechanism underlying morphine analgesic tolerance still remains unresolved. We …
The mechanism underlying morphine analgesic tolerance still remains unresolved. We …
American Society for Enhanced Recovery and Perioperative Quality Initiative joint consensus statement on perioperative management of patients on preoperative …
DA Edwards, TL Hedrick, J Jayaram… - Anesthesia & …, 2019 - journals.lww.com
Enhanced recovery pathways have quickly become part of the standard of care for patients
undergoing elective surgery, especially in North America and Europe. One of the central …
undergoing elective surgery, especially in North America and Europe. One of the central …
Prescription opioid use among opioid-naive women undergoing immediate breast reconstruction
Background: Cancer patients may be particularly vulnerable to the deleterious effects of
prolonged opioid use. The authors explored the factors that influence postoperative opioid …
prolonged opioid use. The authors explored the factors that influence postoperative opioid …
The gut microbiome and the mechanism of surgical infection
JC Alverdy, SK Hyoju, M Weigerinck… - Journal of British …, 2017 - academic.oup.com
Background Since the very early days of surgical practice, surgeons have recognized the
importance of considering that intestinal microbes might have a profound influence on …
importance of considering that intestinal microbes might have a profound influence on …