An evidence-based approach to the prescription opioid epidemic in orthopedic surgery

EM Soffin, SA Waldman, RJ Stack… - Anesthesia & …, 2017 - journals.lww.com
Orthopedic surgery is associated with significant perioperative pain. Providing adequate
analgesia is a critical component of patient care and opioids play a vital role in the acute …

Perioperative opioids, the opioid crisis, and the anesthesiologist

DB Larach, JM Hah, CM Brummett - Anesthesiology, 2022 - pubs.asahq.org
Perioperative Opioids, the Opioid Crisis, and the Anesthesiologist | Anesthesiology | American
Society of Anesthesiologists Skip to Main Content Advertisement Umbrella Alt Text Umbrella Alt …

Wide variation and overprescription of opioids after elective surgery

CA Thiels, SS Anderson, DS Ubl, KT Hanson… - Annals of …, 2017 - journals.lww.com
Objective: We aimed to identify opioid prescribing practices across surgical specialties and
institutions. Background: In an effort to minimize the contribution of prescription narcotics to …

Results of a prospective, multicenter initiative aimed at developing opioid-prescribing guidelines after surgery

CA Thiels, DS Ubl, KJ Yost, SC Dowdy… - Annals of …, 2018 - journals.lww.com
Objective: The aim of this study was to conduct a prospective, multicenter survey of patients
regarding postoperative opioid use to inform development of standardized, evidence-based …

Prevalence of preoperative opioid use and characteristics associated with opioid use among patients presenting for surgery

PE Hilliard, J Waljee, S Moser, L Metz, M Mathis… - JAMA …, 2018 - jamanetwork.com
Importance Patterns of preoperative opioid use are not well characterized across different
surgical services, and studies in this patient population have lacked important self-reported …

Effect of preoperative opioid exposure on healthcare utilization and expenditures following elective abdominal surgery

JF Waljee, DC Cron, RM Steiger, L Zhong… - Annals of …, 2017 - journals.lww.com
Objective: To examine the extent to which preoperative opioid use is correlated with
healthcare utilization and costs following elective surgical procedures. Summary …

Morphine tolerance is attenuated in germfree mice and reversed by probiotics, implicating the role of gut microbiome

L Zhang, J Meng, Y Ban, R Jalodia… - Proceedings of the …, 2019 - National Acad Sciences
Prolonged exposure to opioids results in analgesic tolerance, drug overdose, and death.
The mechanism underlying morphine analgesic tolerance still remains unresolved. We …

American Society for Enhanced Recovery and Perioperative Quality Initiative joint consensus statement on perioperative management of patients on preoperative …

DA Edwards, TL Hedrick, J Jayaram… - Anesthesia & …, 2019 - journals.lww.com
Enhanced recovery pathways have quickly become part of the standard of care for patients
undergoing elective surgery, especially in North America and Europe. One of the central …

Prescription opioid use among opioid-naive women undergoing immediate breast reconstruction

DP Marcusa, RA Mann, DC Cron… - Plastic and …, 2017 - journals.lww.com
Background: Cancer patients may be particularly vulnerable to the deleterious effects of
prolonged opioid use. The authors explored the factors that influence postoperative opioid …

The gut microbiome and the mechanism of surgical infection

JC Alverdy, SK Hyoju, M Weigerinck… - Journal of British …, 2017 - academic.oup.com
Background Since the very early days of surgical practice, surgeons have recognized the
importance of considering that intestinal microbes might have a profound influence on …